Primary Central Nervous System Lymphoma : Clinical Analysis and Prognostic Factors

원발성 중추신경계 임파종의 임상적 특징과 예후인자에 대한 연구

  • Kwon, Heum Dai (Department of Neurosurgery, Yonsei University, College of Medicine) ;
  • Huh, Ryoong (Department of Neurosurgery, CHA University, College of Medicine) ;
  • Kim, Dong Seok (Department of Neurosurgery, Yonsei University, College of Medicine) ;
  • Park, Yong Gou (Department of Neurosurgery, Yonsei University, College of Medicine) ;
  • Choi, Joong Uhn (Department of Neurosurgery, Yonsei University, College of Medicine) ;
  • Chung, Sang Sup (Department of Neurosurgery, Yonsei University, College of Medicine)
  • 권흠대 (연세대학교 의과대학 신경외과학교실) ;
  • 허륭 (포천중문의과대학 분당차병원 신경외과학교실) ;
  • 김동석 (연세대학교 의과대학 신경외과학교실) ;
  • 박용구 (연세대학교 의과대학 신경외과학교실) ;
  • 최중언 (연세대학교 의과대학 신경외과학교실) ;
  • 정상섭 (연세대학교 의과대학 신경외과학교실)
  • Received : 2000.07.08
  • Accepted : 2000.11.14
  • Published : 2000.12.28

Abstract

Objective : The incidence of primary CNS lymphoma(PCNSL) has been increasing recently. The purpose of this study is to establish of prognostic factors and treatment options for PCNSL. Methods : Thirty-one PCNSL patients were treated in our institute between 1985 and 1997. All patients were histologically confirmed via stereotactic biopsy or open biopsy. The authors retrospectively analyzed clinical characteristics of PCNSL and prognostic factors, including histological cell types, immunohistological cell types and treatment options of PCNSL. Our data were statistically analyzed using Kaplan Meier survival curve and multivariated ANOVA test. Results : The clinical and radiological characteristics of PCNSL were resembled to those of other reports. The most common histological subtype was diffuse large cell type(55.5%). In immunohistolgical study, the incidence of T-cell lymphoma(35.7%) was very higher than that of others. The radiotherapy could prolonged patients' survival(p=0.021). One-year and 3-year survival rate of PCNSL were 66.9% and 45.9%, respectively. One-year survival rate of B cell and T cell lymphoma were 72.7% and 50.0%, respectively. The patients with B-cell lymphoma showed better prognosis than patients with T-cell lymphoma(p=0.049). Conclusion : On the basis of our data, active radiotherapy could prolong patients' survival. the T-cell lymphoma revealed higher incidence than those of other reports and had poor prognosis than that of B cell lymphoma.