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Effects of Chromium Supplementation and Lipopolysaccharide Injection on Physiological Responses of Weanling Pigs

  • Lee, D.N. ;
  • Weng, C.F. ;
  • Yen, H.T. ;
  • Shen, T.F. ;
  • Chen, B.J.
  • Received : 1999.05.06
  • Accepted : 1999.07.19
  • Published : 2000.04.01

Abstract

Sixteen specific pathogen free 4-wk-old crossbred weanling pigs were allotted into a $2{\times}2$ factorial design to evaluate chromium picolinate (CrPic) on growth and physiological responses. Two factors included (1) no Cr or 400 ppb Cr supplementation from chromium picolinate and (2) lipopolysaccharide (LPS) injection on day 21 (d 21) and 35 (d 35) compared to saline application. Plasma samples and rectal temperature were obtained from all piglets before (h 0) and at 2 h (h 2), 4 h (h 4), 8 h (h 8), and 24 h (h 24) after LPS injection ($200{\mu}g/kg$ BW, intraperitoneally). The rectal temperature on d 21 was significantly decreased (p<0.05) of about $0.36^{\circ}C$ with Cr supplementation before LPS injection. After LPS injection, the daily gain of piglets was decreased during d 35-38. Supplementation of Cr had no effect in general on growth performance particularly after LPS injection. The plasma glucose, triglycerides and urea nitrogen concentrations were changed in different ways after LPS injection. Plasma cortisol level was significantly elevated at h 2 after LPS injection on d 21 and d 35. The supplementation of Cr in the diet can delayed plasma cortisol release on d 35. The results suggest that 400 ppb Cr supplementation from CrPic may modulate the physiological response during immune stress in weanling pigs.

Keywords

Chromium;Lipopolysaccharide;Physiological Response;Weanling Pig

Cited by

  1. Effects of Dietary Chromium (III) Picolinate on Growth Performance, Respiratory Rate, Plasma Variables, and Carcass Traits of Pigs Fed High-Fat Diets vol.133, pp.2, 2010, https://doi.org/10.1007/s12011-009-8417-7
  2. The Effects of Dietary Chromium(III) Picolinate on Growth Performance, Vital Signs, and Blood Measurements of Pigs During Immune Stress vol.135, pp.1-3, 2010, https://doi.org/10.1007/s12011-009-8503-x
  3. Effect of Feeding Inorganic Chromium on Growth Performance, Endocrine Variables, and Energy Metabolites in Winter-Exposed Buffalo Calves (Bubalus bubalis) vol.155, pp.3, 2013, https://doi.org/10.1007/s12011-013-9808-3
  4. Chromium supplementation alters the performance and health of feedlot cattle during the receiving period and enhances their metabolic response to a lipopolysaccharide challenge1–3 vol.90, pp.11, 2012, https://doi.org/10.2527/jas.2011-4981
  5. Effect of chromium on bioenergetics and leukocyte dynamics following immunoactivation in lactating Holstein cows vol.101, pp.6, 2018, https://doi.org/10.3168/jds.2017-13899

Acknowledgement

Supported by : National Science Council of the Republic of China