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Phenotype Manipulation by Gene Transfer in Animals - Review -

  • Fujiwara, Y. (Department of Applied Genetics and Physiology, Graduate School of Bio-agricultural Sciences, Nagoya University) ;
  • Park, H.-M. (Department of Applied Genetics and Physiology, Graduate School of Bio-agricultural Sciences, Nagoya University) ;
  • Muramatsu, T. (Department of Applied Genetics and Physiology, Graduate School of Bio-agricultural Sciences, Nagoya University)
  • Published : 2000.02.01

Abstract

Recent progress in molecular biology has made it possible to transfer genes of interest into cells and target tissues of living animals. This enables one to manipulate phenotype of cells and whole animals in selected and intended ways. The consequence of such gene transfer attempts have been the production of various types of "transgenic" animals that cannot be classified by classical nomenclature of exclusively either "transgenic" or "nontransgenic". Emphasis was placed on characterizing two transgenic categories, i.e., "transfectgenic and somatotransgenic" and "genuine transgenic" animals basically from a view point of their use for therapeutic purposes. Current state of art and possible solutions for problems encountered at present are discussed.

Keywords

Genuine Transgenic;Transfectgenic;Somatotransgenic;Localized In Vivo Gene Transfer;Xenotransplantation;Recombinant Protein Production