DOI QR코드

DOI QR Code

Effects of Vitamin A on the Antioxidant Systems of the Growing Chicken

  • Surai, P.F. (Department of Biochemistry and Nutrition, Scottish Agricultural College) ;
  • Kuklenko, T.V. (Department of Physiology, Biochemistry and Nutrition, Poultry Research Institute)
  • Received : 2000.01.18
  • Accepted : 2000.03.08
  • Published : 2000.09.01

Abstract

The present study was conducted to evaluate effects of the increased dietary vitamin A supplementation on the vitamin A, vitamin E and ascorbic acid concentrations in the plasma and liver and activities of some enzymes in the liver of the growing chicken. One hundred and twenty female chickens at 4 weeks of age were divided in 6 equal groups in accordance with their body weight. They were housed in cages and fed on standard wheat-barley-based broiler diet balanced in the major nutrients. Vitamin A was supplemented in the form of retinyl acetate. Control diet was supplemented with 10 IU/g and experimental feeds were supplemented with 50, 100, 500, 1000 and 2000 IU/g. At days 42 and 56 of the development 8 chickens from each group were killed, plasma and liver were collected for vitamin and enzyme analyses. The increased vitamin A supplementation was associated with its increased accumulation in the liver and with a reduction of ${\alpha}-tocopherol$ concentrations in the plasma and liver. The blood plasma was more resistant to vitamin A concentration changes and the retinol level was elevated only when the vitamin A dose exceeded 100 IU/g feed. Ascorbic acid concentration in the liver was elevated when moderately high vitamin A supplementation was used but significantly decreased at the highest vitamin A dose. Similar changes were observed with glycogen concentration in the liver. Activities of hexokinase, glucose-6-phosphatase and lactate dehydrogenase in the chicken liver were also dependent on vitamin A supplementation, decreasing with highest vitamin A doses. Therefore the observations showed that the vitamin A excess compromises antioxidant system of the growing chickens suggesting that prooxidant activity may be responsible for at least part of the toxicity of vitamin A.

Cited by

  1. vol.45, pp.4, 2014, https://doi.org/10.1111/jav.00360
  2. Combined effects of retinol, ascorbic acid and α-tocopherol on diurnal variations in rectal temperature of Black Harco pullets subjected to heat stress pp.1432-1254, 2016, https://doi.org/10.1007/s00484-016-1157-4