Effects of Short-term Immobilization Stress on the Mouse Serum Concentrations of Cortisol and Dehydroepiandrosterone Sulphate

단기 속박스트레스가 마우스 혈청 Cortisol, Dehydroepiandrosterone Sulphate 농도에 미치는 영향

  • 차정호 (전북대학교 수의과대학) ;
  • 최광수 (우석대학교 이공대학 동물자원학과) ;
  • 최형송 (우석대학교 이공대학 동물자원학과)
  • Published : 2000.03.01


We have investigated the effect of short-term immobilization stress on the serum concentrations of cortisol and DHEAS in BALB/c male mice. Serum cortisol and DHEAS concentrations were measured by radioimmunoassay(RIA). We found there were significantly increased in the cortisol levels in 30 min-stressed group(Ⅰ-30N) compared with control(C) group (p<0.01), and also increased with significance in 120 min-stressed group(I-120N) compared with C group(p<0.01). Cortisol concentrations were significantly increased in both 30 min-stressed group(Ⅰ-30T), and 120 min-stressed group(Ⅰ-120T) compared with C group(p<0.01). The sustained increase of cortisol levels were observed in both SG treated and SG non-treated group. Serum cortisol levels were lower in SG treated group than SG non-treated group with significance(p<0.01). By contrast, DHEAS levels were slightly decreased without significance in Ⅰ-30N, but significantly decreased in Ⅰ-120N compared with C group(p<0.01). There were slightly decreased in the DHEAS levels in Ⅰ-30T, but significantly decreased in Ⅰ-120T compared with C group(p<0.01). However, SG treatment did not induce any significant changes of DHEAS levels in both 30 min and 120 min-stressed group. Though short-term immobilization stress, the continuous decline of DHEAS levels were observed. Therefore, these results show that short-term immobilization stress affects the serum concentrations of cortisol and DHEAS in mice.