Antitumor and Immunomodulatory Activity of Lycoperdon pedicellatum

긴꼬리말불버섯 (Lycoperdon pedicellatum)의 항암 면역활성

  • 정경수 (충남대학교 약학대학 미생물면역학교실) ;
  • 김진향 (충남대학교 약학대학 미생물면역학교실)
  • Published : 2000.10.01

Abstract

Protein-polysaccharide fractions separated from nine Korean wild mushrooms were subjected to an in vitro screening test for lymphoblastogenic activity. Of these, PPLP, the protein-polysaccharide fraction of Lycoperdon pedicellatum, showed the most potent activity and were further investigated for its antitumor activity. When intraperitoneally injected into ICR mice once daily for six days at a dose of 30 mg/kg, PPLP strongly inhibited the growth of sarcoma 180 tumor cells, showing the inhibition ratio of 97.6%. PPLP also showed in vitro inhibitory activity on sarcoma 180 or leukemia L1210 at the concentration of 500 $\mu\textrm{g}$/$m\ell$ or higher. These results strongly suggest that PPLP might exert its antitumor activity through immunostimulation as well as inhibitory activity on the tumor cells.

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