Antioxidative Activity of Tannins from Rubus coreanum

복분자딸기에서 분리한 탄닌화합물의 항산화작용

  • Published : 2000.08.01


Two ellagitannins, pedunculagin and 2,3-(S)-Hexahydroxydiphenoyl (HHDP)-D -glucose and three condensed tannins, (+)-catechin, (-)-epicatechin and procyanidin B-4 which were isolated from Rubus coreanum were evaluated for their antioxidative effects with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and lipid peroxidation generation system mediated by addition of $H_2O$$_2$to rat liver homogenate (TBARS). The ellagitannins, 2,3-(S)-HHDP-D-glucose and pedunculagin, showed more potent antioxidative activities by DPPH and TBARS than condensed tannins.


  1. 한국식물도감(木本部) 정태현
  2. 本草綱目草部 v.18 覆盆子, 本草綱目通釋
  3. HOIKUSHA v.1 The Encyclopedia of Wakan-Yuku (Traditional Sino-Japanese Medicines) with Color Pictures Namba, T.
  4. Medicinal Plants of East and Southeast Asia Attributed Properties and Uses Perry, L.M.
  5. Kor. J. Pharmacogn v.26 Tannins from Rubus coreanum Lee, Y.A.;Lee, M.W.
  6. Yakhak Hoeji v.39 Phenolic Compounds from the leaves of Rubus coreanum Lee, M.W.
  7. Yakhak Hoeji v.40 Tannins from the leaves of Rubus coreanum Kim, M.S.;Pang, G.C.;Lee, M.W.
  8. Chem. Pharm. Bull. v.31 Mechanism of the Blood Urea Nitrogen-decreasing Activity of Rhatannin from Rhei Rhizoma in the Rat.Ⅰ Shibutani, S.;Nagasawa, T.;Oura, H.;Nonaka, G.;Nishioka, I.
  9. Gendaitoyoigaku v.7 Psychotropic effects of Rhubarb Ueki, S.;Fugiwara, M.;Nishioka, I.;Nonaka, G.
  10. Chem. Pharm. Bull. v.38 Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHIRSP) Ingesting Persimmom Tannin Uchida, S.;Ohta, H.;Niwa, M.;Mori, A.;Nonaka, G.;Nishioka, I.;Ozaki, M.
  11. Planta Med. v.34 Pharmacological Studies on Lindera Umbellatae Ramus, IV. Effect of Condensed Tannins and Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mices Ezaki, N.;Kato, M.;Takizawa, N.;Morimoto, S.;Nonaka, G.;Nishioka, I.
  12. Chem. Pharm. Bull. v.33 Inhibitory Effect of Tannins on Hyaluronidase Activation and on the Degranulation from Rat Mesentery Mast Cells Kakegawa, H.;Matsumoto, H.;Endo, K.;Satoh, T.;Nonaka, G.;Nishioka, I.
  13. Chem. Pharm. Bull. v.33 Inhibition of Angiotensin-Converting Enzyme in Crude Drug Ⅱ Inokuchi, T.;Nagamatsu, A.;Nonaka, G.;Nishioka, I.
  14. Japan J. Pharmaco. v.43 Inhibitory effects of condensed Tannins on Angiotensis converting Enzyme Uchida, S.;Ikari, N.;Ohta, H.;Niwa, M.;Nonaka, G.;Nishioka, I.;Ozaki, M.
  15. J. Natr. Prod. v.55 Antitumor Agents, 129. Tannins and Related Compounds as Selective Cytotoxic Agents Kashiwada, Y.;Nonaka, G.;Nishioka, I.;Chang, J.-J.;Lee, K.-H.
  16. Bioorg. Med. Chem. Letters v.2 Tannins as Selective Inhibitors of Protein Kinase C Kashiwada, Y.;Nonaka, G.;Nishioka, I.;Ballas, L.M.;Jiang, J.B.;Janzeng, W.P.;Lee, K.-H.
  17. J. Natr. Prod. v.53 Anti-AIDS Agents, 2;Inhibitory Effects of Tannins on HIV Reverse Transcriptase and HIV Replication In H9 Lymphocyte Cells Nonaka, G.;Nishioka, I.;Nishizawa, M.;Yamagishi, T.;Kashiwada, Y.;Dutschman, G.E.;Bonder, A.J.;Kilkuskieg R.E.;Cheng, Y.-C.;Lee, K.-H.
  18. Tannin and Related compounds as Anti-HIV Agents, Natr. Prod. as Anti-Viral Agents Lee, K.-H.;Kashiwada, Y.;Nonaka, G.;Nishioka, I.;Nishizawa, M.;Yamagishi, T.;Bonder, A.J.;Kilkuskie, R.E.;Cheng, Y.-C.
  19. Chem. Pharm. Bull. v.37 Effects of the interaction of tannins with co-existing substances. VI. Effects of tannins and ralated polyphenols on superoxide anion radical and on 1,1-diphenyl-2-picrylhydrazyl radical Hatano T.;Edamatsu R.;Hiramatsu M.;Mori A.;Fujita Y.;Yasuhara T.;Yoshida T.;Okuda T.
  20. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa H.;Ohishi N.;Yagi K.
  21. Natural Medicines v.51 Antiperoxidation Activity of Traditional Chinese Prescriptions and their Main Crude Drugs In vitro Yokozawa, T.;Dong, E.;Liu, Z.W.;Oura, H.