Biocompatibility of Biodegradable Films by Natural Polymers

천연고분자 분해성 필름의 생체적합성 연구

  • Hwang, Sung Kwy (Department of Chemical Engineering, Myong Ji University) ;
  • Lee, Ki Chang (Department of Chemical Engineering, Myong Ji University) ;
  • Rhim, Kook Hwan (Department of Health Administration, Korea University)
  • 황성규 (명지대학교 화학공학과) ;
  • 이기창 (명지대학교 화학공학과) ;
  • 임국환 (고려대학교 보건대학 보건행정과)
  • Received : 1999.07.31
  • Accepted : 1999.09.09
  • Published : 1999.10.10

Abstract

Recently there has been an explosion of interest in the topic of biodegradable polymers for medical applications. In this study, films were prepared by solution casting method using natural polymers (xanthan, locust bean, guar gum, chitosan and algin) as biomaterials. Biocompatibility of films prepared from natural polymer as a skin implant was evaluated. These biodegradable films were subcutaneously implanted in the back of rats and their biodegradability was investigated by the evaluation of changes in structure, film weight and hematology as a function of time for the biotransformation. The result of rats test showed that locust bean and guar gum induced some suspects of non-biocompatibility in the tissue by foreign body reaction 24 and 48 hrs after implantation. These results showed the potential of partial biodegradable films prepared from natural polymer for ideal skin biomaterials at short period.

Keywords

biocompatibility;biomaterial;natural polymer;biotransformation

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