Effect of Softcapsule Fill Formulation on the Stability and the Disintegration Time of Ginkgo Biloba Extract

연질캅셀 제제 처방이 은행잎 엑스의 안정성 및 붕해 시간에 미치는 영향

  • Kim, Young Soo (Department of Industrial Chemistry, Dankook University) ;
  • Kim, Su-Dong (Department of Applied Chemistry, Ajou University) ;
  • Yoon, Sung-Hwa (Department of Applied Chemistry, Ajou University)
  • 김영수 (단국대학교 공업화학과) ;
  • 김수동 (아주대학교 공업화학과) ;
  • 윤성화 (아주대학교 공업화학과)
  • Received : 1999.01.25
  • Accepted : 1999.08.06
  • Published : 1999.10.10

Abstract

In order to increase the stability of Ginkgo Biloba extract, we investigated the effect of three different fill formulations(SBO, PEG400, and PEG600 fill types) on the stability of Ginkgo Biloba extract in three different shell formulations (ssmb, smb and gmb shell types). The stabilities of each types were evaluated by testing their disintegration time sunder the condition of $40^{\circ}C$, 75% relative humidity(RH) for 8 weeks. The formulation of Ginkgo Biloba extract with ssmb and PEG600 formulation type showed the best stability among them.

Keywords

formulation;stability;disintegration;ginkgo biloba extract softshell

References

  1. Effects of Ginkgo Biloba Extract on Organic Cerebral Impairment A. Agnoli;J. R. Ropin;W. V. Weitbrecht
  2. 대한민국 특허청 특허공보 제4333호 공고번호 96-2179 엄기안;민동선;김용수;박병욱
  3. J. Pharm. Sci. v.83 G. A. Digenis;T. B. Gold;V. P. Shah
  4. Physicians Desk Reference(50th ed.) Medical Economics Co.
  5. The theory and Practice of Industrial Pharmacy(3rd ed.) L. Lachman;A. Herbert;L. Joseph;L. Kanig
  6. Handbook of Pharmaceutical excipients(2nd ed.) AMERICAN PHARMACEUTICAL ASSOCIATION
  7. Pharmaceutical Principles of Solid Dosage Form J. T. Carstensen
  8. KIMS MINS Korea v.11
  9. 일반시험법 대한약전 제6개정 보건사회부
  10. J. Pharm. Sci. v.86 Carey B. Bottom;Marijo Clark;j. T. Carstensen