Effect of Softcapsule Fill Formulation on the Stability and the Disintegration Time of Ginkgo Biloba Extract

연질캅셀 제제 처방이 은행잎 엑스의 안정성 및 붕해 시간에 미치는 영향

  • Kim, Young Soo (Department of Industrial Chemistry, Dankook University) ;
  • Kim, Su-Dong (Department of Applied Chemistry, Ajou University) ;
  • Yoon, Sung-Hwa (Department of Applied Chemistry, Ajou University)
  • 김영수 (단국대학교 공업화학과) ;
  • 김수동 (아주대학교 공업화학과) ;
  • 윤성화 (아주대학교 공업화학과)
  • Received : 1999.01.25
  • Accepted : 1999.08.06
  • Published : 1999.10.10


In order to increase the stability of Ginkgo Biloba extract, we investigated the effect of three different fill formulations(SBO, PEG400, and PEG600 fill types) on the stability of Ginkgo Biloba extract in three different shell formulations (ssmb, smb and gmb shell types). The stabilities of each types were evaluated by testing their disintegration time sunder the condition of $40^{\circ}C$, 75% relative humidity(RH) for 8 weeks. The formulation of Ginkgo Biloba extract with ssmb and PEG600 formulation type showed the best stability among them.


formulation;stability;disintegration;ginkgo biloba extract softshell


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