Effects of Vitamin E and Vitamin C Supplementation on the Decrease in Cognitive Function Induced by Scopolamin

비타민 E와 비타민 C 첨가가 Scopolamine에 의한 인지능력 감퇴에 미치는 영향

  • 안향숙 (중앙대학교 사범대학 가정교육학과)
  • Published : 1999.04.01


With the increasing elderly population in Korea, dementia has become a mojor health problem in Korea. Several studies have been conducted on the association between dementia and dietary intake, especially vitamin E and vitamin C. The purpose of this study was to investigate the effect of vitamin E and vitamin C supplementation on the decrease in cognitive function induced by scopolamine(300mg/kg) in rats. Rats were divided into three groups : control, vitamin C, and vitamin E supplementation(2.4g Vit C or Vit E /100g diet) and fed the diets for 6 weeks. There were significant decreases in active avoidance response and brain acetylcholinesterase activity in the control group, but no significant differences were observed in the vitamin E and C groups after scopolamine treatment. Brain dopamine concentration of vitamin E and C groups was significantly higher than those of control group after scopolamine injection. The concentrations of brain norepinephrine also showed similar tendence, even though it was not statistically significant. These results indicate that vitamin E and vitamin C may protect against the cognitive function decrease induced by scopolamine. However, it is still unclear how vitamin E and C influence brain neurotransmitters and improve cognitive function. Further study is need to elucidate the role of vitamin E and C supplementation in the prevention of dementia.


  1. Aging-Daewoo science library-. Kim SH;Kim WY
  2. Future estimation of population Board of Statistics.
  3. Dementia and Aging -Ethics, Values, and Policy Choices-. Binstock RH;Post SG;Whitehouse PJ
  4. Alzheimer's-A caregiver's guide and sourcebook-. Gruetzner H
  5. JAMA v.271 Influence of education and occupation on the incidence of Alzheimer's disease Stern Y;Gurland B;Tatamichi TK;Tang MX;Wilder D;Mayeux R
  6. Am J Epidemiol v.143 Variables associated with cognitive function in elderly California seventhday adventists Raser GE;Singh PN;Bennett H
  7. Hypertension v.9 Clinical significance of cognitive performance by hypertensive patients Elias MF;Robbins MA;Schultz NR;Streeten DH;Elias PK
  8. Family nutritional -Daewoo science library-. Kim SH;Yoo CH;Kim SH;Lee SS;Kang MH;Chang NS
  9. Am J Clin Nutr v.65 Nutritional status and cognitive functioning in a normally aging smaple : A6-y reassessment Rue AL;Koehler KM;Wayne SJ;Chiulli SJ;Haaland KY;Garry PJ
  10. Nutrition Reviews v.37 no.5 Dietary influences on the Synthesis of Neurotransmitters in the brain Growdon JH;Wurtman RJ
  11. Kor J Diet Cult v.7 no.2 A study on the realtion between dietary intake and cognitive function in the elderly Park SO;Han SS;Ko YS;Kim YJ;Lee HS;Kang NE;Lee JH;Kim WK;Kim SH
  12. Am J Clin Nutr v.55 Nutritional factors in physical and cognitive function of elderly people Rosenberg IH;Miller JW
  13. Nueroscience Letter v.174 no.1 Concentrations of gamma-tocopherol and its quinone derivative in cerebrospinal fluid from patients with vascular dementia of the Binswanger type and Alzheimer type dementia Tohgi H;Abe T;Nakanishi M;Hamato F;Sasaki K;Takahashi S
  14. Age Aging v.21 no.2 Plasma concentrations of vitamin A and E and carotenoids in Alzheimer's disease Zaman Z;Roche S;Fielden P;Frost PG;Niriella DC;Cayley ACD
  15. Gerontology v.35 no.5-6 Lipid peroxidation and free radical scavengers in Alzheimer's disease Jeandel C;Nicolas MB;Dubois F;Nabet-Belleville F;Penin F;Cuny G
  16. N Engl J Med v.336 no.17 A controlled trial of selegilline, alpha-tocopherol, of both as treatment for Alzheimer's disease. The Alzheimer's disease cooperative study Sano M;Ernesto C;Thomas RG;Klauber MR;Schafer K;Grudman M;Woodbury P;Growdon J;Cotman CW;Pfeiffer E;Schneider LS;Thal LJ
  17. Medical Hypotheses v.48 no.5 The possible role of peroxynitrite in Alzheimer's disease : A simple hypothsis that could be tested more thoroughly Van Dyke K
  18. JAMA v.249 Association between nutritional status and cognitive functioning in a healthy population Goodwin JS;Good JM;Gerry PJ
  19. Arch Gerontol Geriatr v.21 no.1 Ascorbic acid in cerebrospinal fluid -A possible protection against free radicals in the brain Barabas J;Nagy E;Degrell I
  20. Europ J Clin Nutr v.42 no.7 Dietary intakes and nutritional status of old people with dementia living at home in Oslo Nes M;Sem SW;Rousseau B;Bjorneboe GEA;Engedal K;Trygg K;Pedersen JI
  21. Acta Neurol Scand v.92 no.2 Posatirelin for the treatment of late-onset Alzheimer's disease : A double blind multicentre study vs citicoline and ascorbic acid Parnetti L;Ambrosoli L;Abate G;Azzini C;Balestreri R;Barotorelli L;Bordin A;Crepaldi G;Cristianini G;Cucinotta D;Cuzzupoli M;De Candia O;Fabris F;Maggioni M;Scarpa R;Villardita C;Girardello R;Poli A;Senin U
  22. Neurobiology of Learning & Memory v.64 no.2 The effects of ascorbic acid and oxiracetam on scopolamine-induced amnesia in a habituation test in aged mice de Angelis L;Furlan C
  23. The annual report of KFDA v.1 Biochemical study on Alzheimer's disease(I) Kang SY;Kim SH;Kim TG;Jung KK;Ko HS;Huh YB;Lee SD;Lee YK
  24. Psychopharmacology v.83 Cholinergic learning deficits in the marmoset produced by scopolamine and 1CV hemicholinium Ridley BM;Barratt NG;Baker HF
  25. Natural and Synthetic Neurotoxins Harvey AL
  26. Biochemical Pharmacology v.7 A new and rapid colorimetric determination of acetylcholinesterase activity Ellman GL;Courtney D;Andres V Jr;Featherstone RM
  27. Kor J Nutr v.29 no.1 Effect of DHA and environmental enrichment on brain fatty acid composition and acetylcholinesterase activity Kim MJ;Kim SH
  28. J Chrom v.309 Rapid automated analysis of biogenic amines and their metabolites using reversed-phase high performance liquid chromatography with electrochemical detection Saller CF;Salama AI
  29. Brain Res v.418 Dopamine mediates the light-evoked suppression of serotonin N-acetyltransferase activity in retina Iuvone PM;Boatright JH;Bloom MM
  30. SAS and statistics consulting Cho IH
  31. Europ J Pharm v.309 no.2 Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats Riekkinen P Jr;Schmidt B;Stefanski R;Kuitunen J;Riekkinen M
  32. J Ethnopharmacology v.50 no.2 Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain Hirokawa S;Nose M;Ishige A;Amagaya S;Oyama T;Ogihara Y
  33. Brain Res v.171 Neurotransmitter-related enzymes in senile dementia of the Alzheimer type Davis P
  34. Kor J Nutr v.28 no.8 Influence of dietary linolenic acid/linoleic acid ratio on brain lipid composition and acetylcholinesterase activity in different aged rat Yoon GA
  35. Lancet v.349 no.9068 Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease Iyo M;Namba H;Fukushi K;Shinotoh H;Nagatsuka S;Suhara T;Sudo Y;Suzuki K;Irie T
  36. Medical Hypothesis v.47 no.5 The significance of the activity of CSF cholinesterases in dementias Shen ZX
  37. Annals of Clinical & Laboratory Science v.26 no.4 Laboratory examinations correlated with severity of dementia Oishi M;Mochizuki Y;Yoshihashi H;Takasu T;Nakano E
  38. Am J Chinese Med v.24 no.3-4 Regulatory effect of danggui-shaoyaosan on central cholinergic nervous system dysfunction in mice Itoh T;Michijiri S;Murai S;Saito H;Nakamura K;Itsukaichi O;Fujiwara H;Ookubo N;Saito H
  39. Br J Clin Practice v.48 no.6 Therapy options in Alzheimer's disease Gottfries CG
  40. JAMA v.271 no.13 A 30-week randomized controlled trial of high-dose Tacrine in patients with Alzheimer's disease Knapp MJ;Knopman DS;Solomon PR;Pendlebury WW;Davis CS;Gracon SI
  41. N Engl J Med v.327 no.18 A double-blind, placebo-controlled multicenter study of Tacrine for Alzheimer's disease Davis KL;Thal LJ;Gamzu ER;Davis CS;Woolson RF;Gracon SI;Drachman DA;Schneider LS;Whitehouse PJ;Hoover TM;Morris JC;Kawas CH;Knopman DS;Earl NL;Kumar V;Doody RS
  42. JAMA v.268 no.18 A controlled trial of Tacrine in Alzheimer's disease Farlow M;Gracon SI;Hershey LA;Lewis KW;Sadowsky CH;Dolan-Ureno J
  43. Journal of Pharmacology & Experimental Therapeutics v.277 no.2 Pharmacological evaluation of novel Alzheimer's disease therapeutics : Acetylcholinesterase inhibitors related to galanthamine Bores GM;Huger FP;Petko W;Mutlib AE;Camacho F;Rush DK;Selk DE;Wolf V;Kosley RW JR;Davis L;Vargas HM
  44. Neuroscience v.76 no.1 Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus Chapman CA;Yeomans JS;Blaha CD;Blackburn JR
  45. Ann Nucl Med v.8 no.4 Assessment of dopamine metabolism in brain of patients with dementia by means of 18F-fluorodopa and PET Itoh M Meguro K;Fujiwara T;Hatazawa J;Iwata R;Ishiwata K;Takahashi T;Ido T;Sasaki H
  46. Nihon Shinkei Seishin Yakurigaku Zasshi v.16 no.3 Experimental techniques for developing new drugs acting on dementia -Alzheimer's disease animal model induced by beta-amyloid protein Nitta A;Nabeshima T
  47. Br Med J v.288 no.31 Neurochemical characteristics of early and late onset types of Alzheimer's disease Rossor MN;Iversen Ll;Reynolds GP;Mountjoy CQ;Roth M
  48. Kor J Psychopharmacol v.3 no.1 Biochemistry and molecular biology of dementia Suh Y
  49. Biological Psychiatry v.38 no.3 Plasma 3-methoxy-4-hydroxyphenylglycol(MHPG) and clinical symptoms in Alzheimer's disease Lawlor BA;Bierer LM;Ryan TM;Schmeidler J;Knott PJ;Williams LL;Mohs RC;Davis KL
  50. J Neurol Sci v.136 no.1-2 Plasma catechols and monoamine oxidase metabolites in untreated Parkinson's and Alzheimer's diseases Ahlskog JE;Uitti RJ;Tyce GM;O'Brien JF;Petersen RC;Kokmen E
  51. Biological Psychiatry v.34 no.7 Autonomic dysfunction in patients with dementia of the Alzheimer type Vitiello B;Veith RC;Molchan Se;Martinez RA;Lawlor BA;Radcliffe J;Hill JL;Sunderland T
  52. Pharmacology Biochemistry & Behavior v.57 no.1-2 Noradrenergic DSP-4 lesions aggravate impairment of working memory produced by hippocampal muscarinic blockade in rats Ohno M;Yoshimatsu A;Kobayashi M;Watanabe S
  53. Behavioural Brain Research v.78 no.2 The role of brain noradrenaline in cortical activation and behavior : A study of lesions of the locus coeruleus, medial thalamus and hippocampusneocortex and of muscarinic blockade in the rat Vanderwolf CH;Baker GB
  54. Fundamental aspects in nutrition and health The vitamins Gerald F;Combs JR
  55. Nutritional, biochemical, and clinical aspects Handbook of vitamins Lawrence JM