Production of Angiotensin I Converting Enzyme Inhibitory Peptides from Bovine Blood Plasma Proteins

도축 폐혈액 단백질로부터의 Angiotensin I Converting Enzyme 저해 펩타이드의 생산

  • Published : 1999.10.01

Abstract

For the production of angiotensin I converting enzyme inhibitory peptides as a material for antihypertensive functional foods from animal blood produced in slaughterhouse, the optimum condition for enzymatic hydrolysis to yield a peptide fraction of the highest activity were investigated with a respect of industrial production. Among several industrially-usable enzymes tested, $Alcalase^?$ produced hydrolysates of the highest activity from total plasma and purified albumin. $IC_50$ values of albumin hydrolysate and its third fraction separated by gel chromatography were 0.5 and 0.02 mg/mL, respectively. The fraction was found to be obtained by a simple ultrafiltration using a membrane of MW cutoff 1,000. The possibility for the industrial production of antihypertensive peptides from animal blood plasma protein was suggested.

References

  1. 미트저널 국내통계-도축실적 미트저널사
  2. 식육의 과학과 이용 박형기;오홍록;문윤희;강종옥;김언현;김천제;오동환;신현길;박태규;하정욱;이근택;이영진;박창일;이보명;김안규;문영덕
  3. Animal By-Product Processing Blood Utilization Ockerman, H. W.;C. L. Hansen
  4. Trends Food Sci. Tech. v.4 Angiotensin-converting Enzyme Inhibitors Derived from Food Proteins Ariyoshi, Y.
  5. Biopolymer v.43 Antihypertensive Peptides from Food Proteins Yamamoto, N.
  6. 化學の生物 v.29 食品タンパク質に由來する生理活性ぺプチド 千葉英雄;吉川正明
  7. Biochem. BioPhys. Res. Commun. v.204 Inhibition and Inhibition Kinetics of Angiotensin Converting Enzyme Activity by Hemorphins, Isolated from a Peptic Bovine Hemoglobin Hydrolysate Zhao, Q.;F. Sannier;I. Garreau;D. Guillochon;J. M. Piot
  8. 日本特許 平7-188283 新規なトリペプチドおよびアンジオテンシン變換酵素沮害制 末網 陽子
  9. Biotech. Tech. v.10 Angiotensin Converting Enzyme Inhibitory Pentapeptide Isolated from Supernatant of Pig Plasma Treated by Trichloroacetic Acid Park, E.;M. Won;H. H. Lee;K. B. Song
  10. 日經バイオ年鑑96/97 アンジオテン變換酵素(ACE)沮害ペプチド 日本産經新聞社
  11. The Plasma Proteins v.Ⅳ Plasma Protein Fractionation Heide, K.;H. Haupt;H. G. Schwick;F.W. Putnam(eds.)
  12. Anal. Biochem. v.150 Measurement of Protein Using Bicinchoninic Acid Smith, P. K.;R. I. Krohn;G. T. Hermanson;A. K. Mallia;F. H. Gartner;M. D. Provenzano;E. K. Fujimoto;N. M. Goeke;B. J. Olson;D. C. Klenk
  13. Biochim. Biophys. Acta v.293 Spectrometric Assay and Properties of Angiotensin-converting Enzyme of Rabbit Lung Cheung, H. S.;D. W. Cushman
  14. The Plasma Proteins v.IV Alpha, Beta, Gamma, Omega- The Structure of the Plasma Proteins Putnam, F.W.;F.W. Putnam(eds.)
  15. Biosci. Biotech. Biochem. v.57 Inhibition of Angiotensin I-converting Enzyme by Bacillus licheniformis Alkaline Protease Hydrolysates Derived from Sardine Muscle Matsui, T.;H. Matsufuji;E. Seki;K. Osajima;M. Nakashima;Y. Osajima
  16. 食品中の生體機能調節物質硏究法 Angiotensin 變換酵素 沮害物質 丸山 進;川岸舜郞
  17. 춘계 공동학술발표회 초록집, 1998년도 한국식품과학회 한국식품영양학회 춘계 공동학술 발표회 및 총회 탈지대두박가수분해물로부터 Angiotensin-I Converting Enzyme 저해 펩티드의 산업적 생산공정 연구 안창원;이호봉;남희섭;신재익;김재훈
  18. Biosci. Biotech. Biochem. v.60 Angiotensin I-Converting enzyme Inhibitors in Autolysates of Squid Liver and Mantle Muscle Wako, Y.;S. Ishikawa;K. Muramoto
  19. Biosci. Biotech. Biochem. v.59 Effects of Angiotensin I-converting Enzyme Inhibitory Substances Derived from Indonesian Dried-salted Fish on Blood Pressure of Rats Astawan, M.;M. Wahyuni;T. Yasuhara;K. Yamada;T. Tadokoro;A. Maekawa
  20. 한국식품과학회지 v.29 no.6 k-Casein의 Chymosin, Pepsin 및 Trypsin 가수분해물에 대한 안지오텐신 변환효소 저해효과의 탐색 오세종;김세헌;김상교;백영진;조경현
  21. 한국식품과학회지 v.27 no.2 된장으로부터 Angiotensin converting Enzyme(ACE) 저해 Peptide의 분획 신재익;안창원;남희섭;이형재;이형주;문태화
  22. Biosci. Biotech. Biochem. v.59 Angiotensin I Converting Enzyme Inhibitory Activities of Various Fermented Foods Okamoto, A.;H. Hanagata;E. Matsumoto;Y. Kawamura;Y. Koizumi;F. Yanagida