Preparation and Biodegradability of Microsphere Prepared from Biodegradable Microgel

생분해성 Microgel로부터 약물을 담지한 Microsphere의 제조 및 그의 생분해성

  • Received : 1998.03.26
  • Accepted : 1998.05.18
  • Published : 1998.08.10

Abstract

Biodegradable microsphere containing bovine serum albumine (BSA) as a model drug were prepared with the microgel based on poly(caprolactone diol) by a modified solvent evaporation method. The influence of the stirring speed, the concentration of microgel and the mixing rate but increased with increasing the concentration of microgel in methylene chloride. The biodegradability of microsphere in 100 unit/mL of lipase solution was investigated. A lot of small pores appeared on the surface of microsphere after 3 hours of incubation time and the pores and cracks were developed with increasing the incubation time and microsphere lost their own shape after 36 hours of incubation time.

Keywords

Microgel;Microsphere;Biodegradable Polymer;Biodegradability

References

  1. J. Pharm. Sci. v.73 Per Artursson;Peter Edman;Timo Laakso;Ingvar Sjoholm
  2. Makromol. Chem. v.190 Masayuki Yokoyama;Shohei Inoue;Kazunori Katoka;Nobuhiko Yui;Teruo Okano;Yasuhisa Sakurai
  3. J. Controlled Release v.15 Vincent Lenaerts;Yves Dumoulin;Mircea Alexandru Mateescu
  4. J. Pharm. Sci. v.79 Nazih Amoury;Hatem Fessi;J. P. Devissaguet;F. Puisieux;S. Benita
  5. Chem. Pharm. Bull. v.36 Yasuaki Ogawa;Hiroaki Okada;Masaki Yamamoto;Tsugio Shimamoto
  6. Pharm. Res. v.7 Hora, M. S.;Rana, R. K.;Nunberg, J. H.;Tice T. R.;Gilley R. M.;Hudson M. E.
  7. Pharm. Res. v.7 Ruiz J. M.;Busnel J. P.;Benoit J. P.
  8. Chem. Pharm. Bull. v.36 Ogawa Y.;Yamamoto M.;Okada H.;Yashiki T.;Shimamoto T.
  9. Int'l. J. Pharm. v.103 O'hagan D. T.;Jeffery H.;Davis, S. S.
  10. Polymer(Korea) K. S. Kim;N. B.Graham
  11. Polymeric Delivery System Patrick Sinko;Joachim Kohn;Magda A. El-Nokaly;David M. Piatt(ed.)
  12. Chem. Pharm. Bull. v.37 Yutaka NIshioka;Miyazaki;Kazuchi Okazaki;Saburo Onhishi;Yasutake Yamamoto;Kenichi Ito
  13. Reactive Polymers v.15 S. Kohjiya;Y. Ikeda;s. Yamashita;S. Yamshita
  14. J. Pharm. Sci. v.79 Toshinobu Seki;Takeo kawaguchi;Hirotaka Endoh;Koxo Ishikawa;Kazuhiko Juni;Masahiro Nakano
  15. Int'l. J. Pharm. v.142 Isabel Soriano;Carmen Evora;Matias LIabres
  16. J. Microencapsulation v.7 Jalil, R.;Nixon, J. R.
  17. Chemical Aspects of Drug Delivery System Neil B. Graham;Jianwen Mao;D. R. Karsa;R. A. Stephenson
  18. Pharmaceutical Research v.8 Smadar Cohen;Toshio Yoshioka;Melissa Lucarelli;Lena H. Hwang;Robert Langer
  19. J. Pharm. Sci. v.81 Takeo kawaguchi;Akiko Tsugane;Kumiko Higashide;Hirotaka Endoh;Tetsuya Hasegawa;Hiromi Kanno;Toshinobu Seki;Kazuhiko Juni;Shoji Fukushima;Masahiro Nakano
  20. Int'l. J. Pharm. v.69 Heya T.;Okada H.;Tanigawara Y.;Ogawa Y.;Toguchi H.
  21. Pharm. Res. v.10 Alonso M. J.;Cohen S.;Park, T. W.;Siber G. R.;Langer R.
  22. Chem. Pharm. Bull. v.39 Hirotaka Endoh;Takeo Kawaguchi;Toshinobu Seki;Tetsuya Hasegawa;Kazuhiko Juni