Effect of Lidocaine Compounds on the Expansion of Lipid Monolayer at the Air/Water Interface

국부 마취제로 이용되는 Lidocaine 화합물들이 공기/물 계면에 형성된 지질 단분자 막의 팽창효과에 미치는 영향

  • Choi, Suk-Young (Department of Chemical Engineering and Industrial Chemistry, College of Engineering, Hanyang University) ;
  • Oh, Seong-Geun (Department of Chemical Engineering and Industrial Chemistry, College of Engineering, Hanyang University) ;
  • Lee, Ju-Seong (Department of Chemical Engineering and Industrial Chemistry, College of Engineering, Hanyang University)
  • 최숙영 (한양대학교 응용화학공학부) ;
  • 오성근 (한양대학교 응용화학공학부) ;
  • 이주성 (한양대학교 응용화학공학부)
  • Received : 1998.08.21
  • Accepted : 1998.09.21
  • Published : 1998.12.10

Abstract

Lidocaine compounds have widely been used as local anesthetics. Regarding the molecular mechanism for anesthesia by lidocaine, it is proposed that lidocaine molecules penetrate to the hydrophobic region of cell membrane and expand the membrane volume, producing a change in protein conformation that blocks sodium permeability or lidocaine molecules directly adsorb into lidocaine receptor in the protein channel without expanding the cell membrane. But these proposals have never been proven experimentally. In this study, the expansion of cell membrane by lidocaine compounds was investigated by employing lipid monolayer at the air/water interface as the mimetic system of cell membrane. It was found that oil-soluble lidocaine contracted the area/molecule of lipid in the monolayer of phosphatidyl choline, sphingomyelin, DS-PL95E and lipoid, but expanded the monolayer of phosphatidyl ethanolamine only in a certain range of mixing ratios. On the contrary, water-soluble lidocaine-HCl salt expanded the monolayers of all lipids used in this study.

Acknowledgement

Supported by : 한국과학재단

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