Effects of Chitosan Treated with Enzymatic Methods on Glucose and Lipid Metabolism in Rats

키토산의 효소분해물질이 흰쥐의 당 및 지방대사에 미치는 영향

  • 이종미 (이화여자대학교 식품영양학과) ;
  • 조우균 (가천길대학 식품영양과) ;
  • 박혜진 (이화여자대학교 식품영양학과)
  • Published : 1998.09.01

Abstract

This study was conducted to investigate the effets of chitosan and beef tallow at different level on glucose and lipid metabolism in rats. Dietary fot level was 20% and 40%, and chitosan was given at levels of 0%, 3%, and 5%(wt/wt) of diet. Chitosan supplement tended to decrease the serum total lipids, total cholesterol, and triglycerides. HDL cholesterol and HDL cholesterol : total cholesterol ratio tended to increase with 5% chitosan supplementation. LDL cholesterol and VLDL triglyceride tended to decrease with chitosan supplementation. Lipid concentration of liver and epididymal fat pad(EEP) tended to decrease with medium dietary fat and chitosan treatment. fecal excretion of total lipid and triglyceride exhibited a tendency to increase with high fat levels and chitosan. Length of small intestine and gastrointestinal transit time were not affected by dietary fit levels or chitosan supplements. Therefore, it could be suggested that chitosan supplement had beneficial effects on lipid metabolism. (Korean J Nutrition 31(7) : 1112-1120, 1998)

References

  1. Chitin in Nature and Technology Muzzarelli,R.A.A.
  2. Advances in chitin and chitosan An overview of the regulation status and of the safety of chitin and chitosan as food and pharmaceutical ingredients Weiner,M.L.
  3. Food Technol v.38 no.1 Use of chitinous polymers in food Knorr,D.
  4. Science v.212 New facts of research Austin,P.R.;Brine,C.J.;Castle,J.E.;Zikakis,J.P.
  5. Food Technol v.44 no.1 Recivery and utilization of chitin and chitosan in food processing waste management Knorr,D.
  6. J Food Sci v.47 Bioconversion of shellfish chitin waste : Waste pretretement, enzyme production process design and economic analysis Casio,I.G.;Fisher,R.A.;Carroad,P.A.
  7. Proceedings from the 4th International Conference in chitin and chitosan held in Trondheim Production and application of chitin and chitosan Hirano,S.
  8. Proceedings from the 4th International Conference in chitin and chitosan held in Trondheim Chitosan, commercial uses and portential application Sanford,P.S.
  9. J Food Sci v.53 Effects of chitosan on yield and compositional data of carrot and apple juice Knorr,D.;Imeri,A.G.
  10. J Food Sci v.54 Effects of chitosan treatement on the clarity and color of apple juice Soto-peralta,N.V.;Muller,H.A.;Knorr,D.
  11. J Food Sci v.48 Effects of chitin as coagulating aid on protein yield, composition and functionality of tomato seed protein concentrates Latlief,S.J.;Knorr,D.
  12. J Food Sci v.48 Dye binding properties of chitin and chitosan Knorr,D.
  13. J Food Sci v.54 Recovery of amino acids from seafood proceeding waste treatment with a dual chitosanbased ligand-exchange system No,H.K.;Meyers,S.D.
  14. Korean J Food Sci Technol v.24 no.1 A basic study on chitin from krill and kruma prown for industrial use Yang,Y.;Hyun,J.H.;Hwang,Y.H.
  15. Korean J Food Sci Technol v.24 no.6 Physical properties of chitosan film made from crab shell Cho,J.S.;Han,J.J.;Lee,C.H.
  16. Food Industry v.106 Production and development of chitin, chitosan and its derivatives Kim,S.K.
  17. Chitin and chitosan Allan,G.G.;Petron,M.
  18. Research paper of development work on health medical art Production of chito-oilgomer and development of functional food Lee,Y.C.
  19. The Journal of the Population Association of Korea v.8 no.2 Recent pattern of mertality in korea. Choe,E.H.;Byun,Y.C.
  20. Report of investigation into national nutrition The ministry of health and welfare
  21. Food balance sheet Korea rural economic institute
  22. Korean J Nutr v.30 no.7 Effect of chitosan and N, O-Carboxymethyl Chitosan of different sources and molecular weights on cadmium toxicity Bae,K.H.;Kim,M.K.
  23. Effects of chitosan from different molecular weight on lipid metabolism in rats Son,B.K.
  24. Properties of hydrolysate and its influence on the quality of model food Ha,S.M.
  25. Research paper of development work on health medical art Production of chito-oligomer and development of functional food Park,H.K.
  26. Adv in Lipid Res v.6 Practical methods for plasma lipoprotein analysis Hatch,F.T.;Lees,R.S.
  27. J Clin Invest v.34 The distribution and chemical composition of ultracentrigually separated lipoproteins in human serum Havel,R.J.;Eder,H.A.;Bragdan,J.H.
  28. Methods in enzymology v.8 Intestinal disaccharidase Dahlqvist,A.;Elizabeth,F.N.;Vivtor,G.
  29. J Biol Chem v.193 Lowey method for protein determination Lowery,O.H.
  30. Am J Clin Nutr v.53 A colorimetric method for determination of total serum lipid based on the sulfuric-phosphovanillin reaction Frings,C.S.;Dunn,R.T.
  31. Standard method of clinical chemostry Total and free cholesterol Zak,B.
  32. Can J Biochem Physiol v.37 A rapid method of total lipid extraction and purification Bligh,E.G.;Dyer,W.J.
  33. J Biol Chem v.226 A simple method for the isolation and purification of total lipids from animal tissue Folch,J.;Lees,M.;Stanley,G.S.H.
  34. Am J Clin Nutr v.33 A novel use of chitosan as a hypocholesteremic agent in rats Sugano,M.;Fujikawa,T.;Hiratsuji,Y.;Nakashima,K.;Hasegawa,Y.
  35. Effects of exercise and different levels of lipid supply on the carbohydrate and lipid metabolism in the rats Kim,H.J.
  36. J Nutr v.66 Effect of dietary level of fat and type of carbohydrate on growth and food intake Yoshida,A.;Harper,A.E.;Elvehjem,C.A.
  37. Am J Clin Nutr v.33 Dietary fibers III. Effects of chronic intake on cholesterol absorption and metabolism in the rat Vahouney,G.V.;Roy,T.;Gallo,L.L.;Story,J.A.
  38. Korean J Nutr v.27 no.4 The effect of dietary fiber feeding on gastrointestinal functions and lipid and glucose metabolism in streptozotocin-induced diabetic rats Park,S.H.;Lee,H.S.
  39. Korean J Nutr v.27 no.10 Effect of dietary chitin and chitosan on cadmium toxicity and lipid metabolism in rats Kim,M.K.;Seol,E.Y.
  40. J Nutr v.126 Rat plasma triglycerides and hepatic fatty and synthesis mRNA, but not apolipoprotein B and A-IV mRNA, respond to dietary fat content Middleton,S.;Schneeman,B.O.
  41. Endocrinology Some effects of chitosan on liver function in the rat LeHoux,J.;Grondin,F.
  42. Br J Nutr v.72 Effect of chitosan on nutrient digestibility and plasma lipid concentration in broiler chickens Razdan,A.;Pettersson,D.
  43. Nutr Rep Int v.18 no.5 Hypocholesterolemic effects of chitosan in chilesterol-fed rats Sugano,M.;Fujikawa,T.;Hiraysuji,Y.;Hasegawa,Y.
  44. Am J Clin Nutr v.38 Comparative effects of chitosan and cholestyramine on lymphatic absorption of lipids in the rat Vahouny,G.V.;Satchihanandam,S.;Cassidy,M.M.;Lightfoot,F.B.;Furda,I.
  45. Korean J Food Sci Technol v.26 no.4 In vitro study on the functionality in digestive tract of chitin and chitosan from crab shell Chang,H.J.;Chun,D.W.;Lee,S.R.
  46. Lipids v.18 The binding of micellar lipids to chitosan Nauss,J.L.;Thompson,J.L.;Naajvary,J.