Multiple Age-Associated Mitochondrial DNA Deletions in Mouse Brain

  • Kim, Jin-Sun (Department of Biology, Sookmyung Women's University) ;
  • Kim, Min-Jung (Department of Biology, Sookmyung Women's University) ;
  • Kwon, In-Sook (National Institute of Agricultural Science and Technology. Division of Molecular Genetics) ;
  • Song, Eun-Sook (Department of Biology, Sookmyung Women's University)
  • Received : 1996.10.29
  • Published : 1997.01.31


Age-dependent deletion of mitochondrial DNA (mtDNA) was detected in mouse brain using PCR method. The size of the deleted fragment was 0.5 kb, 0.9 kb. 1.7 kb and 4.3 kb in the region between cytochrome b gene and ATPase 6 gene. The deleted fragment was increased gradually from 3-month to 22month Direct repeat sequence flanking the deletion in 0.5 kb PCR product was TAAT.


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