Study of Physico-Chemical Properties of N,N-Diacyl, O-Acyl Chitosan Oligomer

N,N-디아실, O-아실 키토산 올리고머의 물리화학적 특성에 관한 연구

  • Lee, Ok-Sub (Dept. of Chem. Tech., College of Eng., Seoul Nat'l Univ) ;
  • Ha, Byung-Jo (Dept. of Skin Care. Seoul Health Junior College) ;
  • Kim, Jun-Oh (Pacific R&D Center) ;
  • Park, Soeng-Kyu (Dept. of Chem. Tech., College of Eng., Seoul Nat'l Univ) ;
  • Lee, Yoon-Sik (Dept. of Chem. Tech., College of Eng., Seoul Nat'l Univ)
  • 이옥섭 (서울대학교 공과대학 공업화학과) ;
  • 하병조 (서울보건전문대학 피부관리과) ;
  • 김준오 (태평양기술연구원 제품개발연구소) ;
  • 박성규 (서울대학교 공과대학 공업화학과) ;
  • 이윤식 (서울대학교 공과대학 공업화학과)
  • Received : 1996.12.13
  • Accepted : 1997.03.25
  • Published : 1997.06.10

Abstract

Chitosan oligomer having aldehyde group at reducing end was prepared by oxidative-deamination reaction of chitosan by using sodium nitrite, and the resulting aldehyde group was redeced to 2,5-anhydro-D-mannitol group. The obtained chitosan oligomer showed an average degree of polymerization(DP) 2 by GPC analysis. It was highly soluble in lipophilic solvents. N,N-diacyl, O-acyl chitosan oligomer was obtained trom the reaction between chitosan oligomer and acyl chloride under 4-dimethoxyaminopyridine catalyst. From DSC measurement, N,N-dilauroyl, O-lauroyl chitosan oligomer showed mesophase region, which was confirmed by polarizing microscope as thermotropic liquid crystalline state. X-ray diffraction pattern revealed that N,N-dilauroyl, O-lauroyl chitosan oligomer was highly crystalline, whereas chitosan oligomer was not.

Keywords

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