Stabilization and Release Behavior of W1/O/W2-Type Multiple Emulsions Using Various Block Copolymer Emulsifier and Stabilizer

다양한 Block Copolymer를 유화제 및 안정화제로 사용한 W1/O/W2-Type 다중에멀젼의 방출거동 및 안정성

  • Haw, Jung-Rim (Dept. of Ind. Chemistry, College of Engineering, Kon Kuk Univ.) ;
  • Kim, Cheol-Hun (Research and Development Center, Evas Cosmetics Co., Ltd.)
  • 허정림 (건국대학교 공과대학 공업화학과) ;
  • 김철훈 (에바스화장품 기술연구소)
  • Received : 1996.06.28
  • Accepted : 1997.07.26
  • Published : 1997.08.10


A new approach to obtain stable $W_1/O/W_2$ multiple emulsions has been studied ; The basis of the interfacial interaction between a PCL-PEO-PCL triblock copolymer and a lipophilic emulsifier in the dispersed oil phase was examined. $W_1/O/W_2$ multiple emulsions were prepared by the two-step method. Arlacel P-l35 was used as a liphophilic emulsifier and Synperonic PE/F 127 as a hydrophilic one. Eutanol-G was used as an oil phase. NaCl was encapsulated within the multiple emulsion droplets as the internal marker and its release rate studies were carried out. The suability of the multiple emulsions have been assessed by measuring Separation Ratios(%) and microscopic observations. The release of NaCl was significantly reduced in $W_1/O/W_2$ multiple emulsions containing PCL-PEO-PCL triblock copolymer(2k-4k-2k or 6k-4k-6k) in the oil phase. It may be concluded that the copolymer and the emulsifier form effective interfacial complex to enhance stability and to control the release rate. The effective diffusion coefficients of the NaCl were estimated as $2.64{\times}10^{-15}s$and $3.23{\times}10^{-16}gcm^2/s$ for the $W_1/O/W_2$ multiple emulsion containing 1.2 wt % of PCL-PEO-PCL triblock copolymers with compositions of 2k-4k-2k and 6k-4k-2k, respectively. The rate of release decreased with the increase of the initial concentration of NaCl. The results were examined in view of Higuchi mechanism. A kinetic model which is similar to the model for release of dispersed drugs from a polymeric matrix was found to be suitable for the release of NaCl from $W_1/O/W_2$ multiple emulsions.



Supported by : 건국대학교


  1. J. Colloid Interface sci. v.57 no.2 Sachio Matsumoto;Yoshiko Kita;Daizo Yonezawa
  2. J. Colloid Interface sci. v.62 no.1 Yoshiko Kita;Sachio Matsumoto;Daizo Yonezaya
  3. Acta Pharmaceutica Succia v.15 no.1 Arne F. Brodin;Dalia R. Kavaliunas;Sylvan G. Frank
  4. Chemistry and Industry v.3 Satnley S. Davis
  5. J. Pharm. Pharmacol. v.34 Natalie J. Morris;B. Warburton
  6. J. of Controlled Release v.3 T. K. Law;T. L. Whateley;A. F. Florence
  7. J. of Controlled Release v.33 Y. Sela;S. Magadassi;N. Garti
  8. Pharm. Aceta Helv. v.66 no.12 Shan Yang Lin;Wen Hsiuwu
  9. Polymeric Surfactants Irja Piirma
  10. Emulsions and Emulsion Technology Kenneth J. Lissant
  11. The Lancet v.771 Multiple Emulsions W. J. Herbert
  12. J. Microencaps ulation v.6 J. A. Omotosho;T. L. Whateley;A. T. Florence
  13. J. Pharm. Sci. v.52 T. Higuchi
  14. Encyclopedia of Emulsion Technology P. Becher