Effects of Kimchi on Tissue and Fecal Lipid Composition and Apolipoprotein and Thyroxine Levels in Rats

흰쥐에서 김치식이가 조직과 분변의 지질조성과 Apo단백 및 Thyroxine 농도에 미치는 영향

  • 권명자 (부산대학교 식품영양학과 및 김치연구소) ;
  • 송영옥 (부산대학교 식품영양학과 및 김치연구소) ;
  • 송영선 (인제대학교 식품영양학과)
  • Published : 1997.06.01

Abstract

This study was carried out to examine whether kimchi has hypolipidemic effect and to know how it exert lipid-lowering effect in rats. Male Sprague-Dawley rats were fed with kimchi-fee diet, or 3%, or 5%, or 10% kimchi diets for 6 weeks. Plasma cholesterol level was lowered in rats fed all concentrations of kimchi diets, and plasma triglyceride(TG) level was lowered in 10% kimchi diet group compared with that of control significantly(p<0.05). Th intake of kimchi lowered VLDL-cholesterol and VLDL-TG levels, whereas increased HDL-cholesterol level significantly(p<0.05). LDL-cholesterol level was lowered only in 5% kimchi diet group and LDL-TG level was lowered in all kimchi diet groups compared with those of control significantly (p<0.05). the intake of 5% and 10% kimchi diets also lowered the levels of hepatic cholesterol, TG, total lipid, and apolipoprotein B, whereas increased the levels of fecal total fat, cholesterol, TG, and apolipoprotein A-1 significantly(p<0.05). Triiodothyronine(T$_3$) level was elevated in rats fed kimchi diet, whereas thyroxine(T$_4$) level was not affected by kimchi treatment. These observations support that the intake of kimchin in rats loweres plasma and hepatic lipid levels by increasing the excretion of TG and cholesterol through feces, by the elevation of T$_3$ level, and by the altered lipoprotein metabolism.

References

  1. 지방영양 김숙희
  2. Am. J. Clin. Nutr. v.45 Monounsaturated fatty acids, plasma cholesterol, and coronary heart disease Grundy, S. M.
  3. 김치의 과학 김치의 영양생리학적 평가 오영주;황인주;Claus Leitzmann
  4. Am. J. Clin. Nutr. v.39 The effect of milk and lactobacillus feeding on human intestinal bacterial enzyme activity Goldin, B. R.;Gorbach, S. L.
  5. Experimenta v.28 Antihypercholesterolemic effect of sulfur containing amino acid, S-methyl-L-cysteme sulfoxide isolated from cabbage Fujiwara, M.
  6. Ernaerung des menschen Elmadfa, I.;Leitzmann, C.
  7. Aeztle, Proxis v.32 Knoblauch al arteriosklerosehemmar Reuter, H. D.
  8. Ind. J. Nutr. Dietet v.21 Effect of ginger on serum cholesterol level Giri, J.;Devi, T. K.;Meeremani, S.
  9. Appl. Environ. Microbiol v.49 Assimilation of cholesterol by Lactobacillus acidophilus Gilland, S. E.;Nelson, c. R.;Maxwell, C.
  10. Official methods of analysis A.O.A.C.
  11. Methods in carbohydrate chemistry v.1 Whistler, R. L.;Wolform, M. L.
  12. J. Assoc. Off. Anal. Chem. v.66 Determination of total dietary fibre in foods and food products. Collaborative study Prosky, L.;Asp, N. C.;Furda, J.;Devries, J. W.;Schweizer, T. F.;Harland, B. F.
  13. Lipoprotein analysis : A practical approach Converse, C. A.;Skinner, R. E.
  14. J. Biol. Chem. v.223 A simple method for the isolation and purification of total lipids from animal tissues Folch, J.;Lees, M.;Stanley, S. H. S.
  15. Anal. Biochem. v.142 A sensitive enzymatic assay for the determination of cholesterol in lipid extract Sale, F. O.;Marchesini, S.;Fishman, P. H.;Berra, B.
  16. J. Biol. Chem. v.193 Protein measurement with the folin phenol reagent Lowry, O. H.;Rosebrough, N. J.;Farr, A. L.;Randoll, R. J.
  17. Br. Med. J. v.2 Effect of two types of fecal steroid and lipid excretion Walters, R. L.;Baird, M. I.;Davies, P. S.;Hill, M. J.;Drasar, B. S.;Southgate, D. A. T.;Green, J.;Morgan, B.
  18. Ann. Med. v.27 Direct anti-atherosclerosis-related effects of garhc Orehkov, A. N.;Tertov, V. V.;Sobenin, I. A.;Pivovarova, E. M.
  19. 한국영양학회지 v.30 고 또는 저콜레스테롤 식이를 먹인 쥐에 있어서 양파, 마늘이 체내 콜레스테롤과 중성지방 수준 및 혈소판 응집에 미치는 영향 강정애;강정숙
  20. J. Nutr. v.120 Pectin isolated from prickly pear (Opuntia sp.) modifies low-density lipoprotein metabolism in cholesterol-fed guinea pigs Femandez, M. L.;Trejo, A.;McNamara, D. J.
  21. 한국영양식량학회지 v.23 Sodium alginate 와 cellulose 가 식후 혈장 lipoprotein 조성과 콜레스테롤 대사에 미치는 영향(11) 강희정;서명자;송영선
  22. J. Nutr. v.122 Effects of dietary fibres on nonfasting plasma lipoprotein and apolipoproteins levels in rats Nishina, P. M.;Schneeman, B. O.;Freedland, R. A.
  23. Atherosclerosis v.22 The protective action of essential oils of onion and garlic in cholesterol-fed rabbits Bordia, A.;Arora, S. K.;Kothari, L. K.
  24. Lipids v.29 Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis Yeh, Y-Y;Yeh, S. M.
  25. Recent Advences in clinical nutrition Influence of regular consumption of sauerkraut and kimchi on various blood parameter. 4th International symposium on clinical nutrition Hwang, I. J.;Oh, Y. J.;Brehme, U.;Michel, P.;Loos, S.;Wamgemann, G. S.;Temme, K.;Leitzmann, C.
  26. J. Nutr. v.119 Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats Ebihara, K.;Schneeman, B. O.
  27. J. Nutr. v.110 Effects of dietary proteins from a variety of sources on plasma lipids and lipoproteins of rats Neves, L. B.;Clifford, C. K.;Kohler, G. O.;De Fremery, D.;Knuckles, B. E.;Cheowtirakul, C.;Miller, M. W.;Weir, W. C.;Clifford, A. J.
  28. J. Nutr. v.112 Effect of garlic on lipid metabolism in rats fed cholesterol or lard Chi, M. S.;Koh, E. T.;Stewart, T. J.
  29. Mordern nutrition in health and disease. 8th Shils, M. E.;Olson, J. A.;Shike, M.
  30. J. Nutr. v.125 Overview of proposed mechanisms for the hypocholesterolemic effect of soy Potter, S. M.
  31. J. Nutr. v.125 Soy protein, thyroid regulation and cholesterol metabolism Forsythe, W. A.