Hmatological and Biochemical Study of F344 and Wistar Rats

F344와 Wistar 랫드의 계통별에 따른 혈액 및 생화학적 연구

  • Cho, Jae-Chon (Division of Hematopathology, Department of Pathology, Korea FDA) ;
  • Jang, Dong-Deuk (Division of Hematopathology, Department of Pathology, Korea FDA) ;
  • Shin, Dong-Whan (Division of Hematopathology, Department of Pathology, Korea FDA) ;
  • Hong, Choong-Man (Division of Hematopathology, Department of Pathology, Korea FDA)
  • 조재천 (식품의약품안전본부 병리부 혈액병리과) ;
  • 장동덕 (식품의약품안전본부 병리부 혈액병리과) ;
  • 신동환 (식품의약품안전본부 병리부 혈액병리과) ;
  • 홍충만 (식품의약품안전본부 병리부 혈액병리과)
  • Published : 1997.04.01

Abstract

The hematology and clinical chemistry data based on the well defined normal data are essential in the safety assessment. It is important that normal values of cliniclal pathology parameters would be optimized to be accurate. So the purpose of this experiment was to compare the ranges of normal data in hematology value and serum chemistry between both sexes of F344 and Wistar rats at 5, 10, 20, 40 and 90 weeks. of age. The neutrophils eosinophils and monocytes increased with age in male Wistar rats. And serum total bilirubin and potassium were highest and alkaline phosphatase was lowest at 90 weeks in Wistar rats. As compared with Wistar rat the serum aspartate aminotransferase of F344 rats increased with age in both sexes but inorganic phosphorus decreased with age. The serum alkaline phosphatase decreased with age and potassium was highest at 90weeks. These normal data would be useful in improving the accuracy of clinical pathology value in the safety assessment.