An Efficient Synthesis of 3-(E)-Hydroxypropenyl Cephem Derivatives, Key intermediates for 3-(E)-Ammoniopro-penylcephalosporing Antibiotics

  • Lee, Yong-Sup (Division of Applied Science, Korea Institute of Science and Technology) ;
  • Lee, Jae-Yeol (Division of Applied Science, Korea Institute of Science and Technology) ;
  • Jeong, Jin-Hyun (Division of Applied Science, Korea Institute of Science and Technology) ;
  • Park, Hokoon (Division of Applied Science, Korea Institute of Science and Technology)
  • Published : 1997.06.01

Abstract

An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylcephem derivatives, key intermediates for the synthesis of 3-(E)-propenylcephalosporins was achieved via Stille coupling reaction of 3-trifloxycephem with 3-(E)-tributylstannylallylic alcohol.