Synthesis and Antitumor Activity of 3-Arylisoquinoline Derivatives

  • Cho, Won-Jea (College of Pharmacy, Chonnam National University) ;
  • Yoo, Su-Jeong (College of Pharmacy, Chonnam National University) ;
  • Park, Myun-Ji (College of Pharmacy, Chonnam National University) ;
  • Chung, Byung-Ho (College of Pharmacy, Chonnam National University) ;
  • Lee, Chong-Ock (Screening Center, Korea Research Institute of Chemical Technology)
  • Published : 1997.06.01

Abstract

In order to study the structure-activity relationship of 7, 8-dimethoxy-2-methyl-3-(4, 5-methylenedioxy-2-vinylphenyl)isoquinoline-1(2H) -one (2), which has exhibited significant antitumor activity, chemical modifications of 2 were performed to yield the corresponding products (3-7). Further systematic uses of an efficient procedure for the synthesis of 3-arylisoquinoline derivatives produced the substituted compounds (9a-9g), which were tested for in vitro antitumor activity against five different human cancer cell lines.