Hepatoprotective Effect of Extracts and Phenolic Compound from Marine Algae in Bromobenzene-treated Rats

해조류 추출물과 페놀성화합물의 in vitro 및 in vivo 간보호활성

  • Choi, Jae-Sue (Department of Nutrition and Food Science, Pukyong National University) ;
  • Song, Sang-Ho (Department of Biological Engineering, Yosu National Fisheries University) ;
  • Choi, Myeong-Rak (Department of Biological Engineering, Yosu National Fisheries University) ;
  • Kim, Kwang-Young (Department of Oceanography, Chonnam National University) ;
  • Choi, Jong-Won (College of Phamacy, Kyongsung University) ;
  • Park, Jong-Cheol (Department of Oriental Medicine Resources, Sunchon National University)
  • 최재수 (부경대학교 식품생명과학과) ;
  • 송상호 (여수수산대학교 생물공학과) ;
  • 최명락 (여수수산대학교 생물공학과) ;
  • 김광용 (전남대학교 해양학과) ;
  • 최종원 (경성대학교 약학과) ;
  • 박종철 (순천대학교 한약자원학과)
  • Published : 1997.12.30

Abstract

The methanol extracts of some marine algae were tested for investigating the effects on the formation of lipid peroxide and the activities of free radical generating enzyme in vitro in bromobenzene-treated rat. The extracts of Enteromorpha compressa, Capsosiphon fulvescens, Gelidium amansii, Hizikia fusiformis, Sargassum siliquastrum and Sargassum thunbergii which decreased the formation of lipid peroxide, inhibited the activity of xanthine and aldehyde oxidases by adding of each extracts. Phloroglucinol isolated from Ecklonia stolonifera reduced bromobenzene-induced hepatic lipid peroxidation. This compound administered daily over one week before intoxication with bromobenzene did not affect the activities of aminopyrine N-demethylase, aniline hydroxylase and glu tathione S-transferase. Epoxide hydrolase activity was decreased by bromobenzene, which was restored by pretreatment of phloroglucinol, The results suggest that the bromobenzene-induced hepatic lipid peroxidation by phloroglucinol is reduced by enhancing the activity of epoxide hydrolase.