Blocking the Acute Radiostrontium Transfer from Placenta In Fetus by Soluble Chitosan in Mice

수용성카이토산에 의한 마우스태반을 통한 태아로의 방사성스트론튬 급성 전이 억제

  • Kim, Young-Ho (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Bom, Hee-Seung (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Kim, Ji-Yeul (Department of Nuclear Medicine, Chonnam University Hospital)
  • 김영호 (전남대학교병원 핵의학과) ;
  • 범희승 (전남대학교병원 핵의학과) ;
  • 김지열 (전남대학교병원 핵의학과)
  • Published : 1997.12.30

Abstract

It has been reported that chitosan has little genetic toxicity as one of natural and nontoxic chelator and reduces the internal retention of radiostrontium in the mouse. This study is to examine that when water soluble chitosan is provided to the mouse on 17 days of pregnancy before and after radiostrontium contamination, how effectively it can inhibit an acute transfer of radiostrontium to fetus through placenta contaminated. Water soluble chitosan powder is mixed with general food for 60 days and 10%(Group 1) and 1%(Group 2) are provided respectively, and it is observed that the group with radiostrontium contamination on 17 days of pregnancy can inhibit more effectively the transfer of radiostrontium to fetus through placenta than control group with general food and the groups (Group 3, Group 4) with 10% and 1% of chitosan powder respectively after radiostrontium contamination (p<0.01, Table 1). It is found that when the pregnant mouse contaminated by radiostrontium on 17 days of pregnancy is prefed by chitosan, the transfer of radiostrontium to fetus through placenta can be inhibited.