An Experimental Study of Radioprotective Effect of Ginseng Alkaloid Fraction on Cellular Damage

방사선 세포 손상에 대한 인삼 Alkaloid 분획의 보호 효과에 관한 실험적 연구

  • 류성렬 (한국원자력연구소 부설 원자력병원) ;
  • 조철구 (한국원자력연구소 부설 원자력병원) ;
  • 김미숙 (한국원자력연구소 부설 원자력병원) ;
  • 유형준 (한국원자력연구소 부설 원자력병원) ;
  • 김성호 (한국원자력연구소 부설 원자력병원) ;
  • 김태환 (원국원자력연구소 부설 원자력병원)
  • Published : 1997.09.30

Abstract

This paper is to assess the effect of Adaptagen as a radioprotector in which main component is alkaloid fraction of ginseng. Evaluation was made in vitro and in vivo study with NIGP(S) mouse by the measurement of regeneration of jejunal crypt cell and micronucleus assay to analyze radioprotective effect of ginseng alkaloid fraction in comparison with that of water fraction after whole body irradiation. The results were as follows, 1. The degree of radiation damage of mouse jejunal crypt cell was diminished in both of alkaloid and water fraction groups compared to control group but more in alkaloid fraction group than water fraction group. Regeneration of mouse jejunal crypt cell was higher both in alkaloid and water fraction groups than control group. 3. In vitro study, frequency of micronucleus was diminished in tendency for the treated groups than control group but statistically insignificant. 4. In vitro study, frequency of micronucleus was diminished in both alkaloid and water fraction groups compared to control group but more in alkaloid fraction group than water fraction group.