Radioprotective Effect of Panax Ginseng in Mouse Bone-marrow

생쥐에서 방사선방호제로서의 인삼효과에 관한 연구

  • Chae, Ki-Moon (Department of Nuclear Medicine, Channam University Hospital) ;
  • Choi, Keun-Hee (Department of Nuclear Medicine, Channam University Hospital) ;
  • Kim, Young-Ho (Department of Nuclear Medicine, Channam University Hospital) ;
  • Kim, Kwang-Yoon (Department of Nuclear Medicine, Channam University Hospital) ;
  • Bom, Hee-Seung (Department of Nuclear Medicine, Channam University Hospital) ;
  • Kim, Ji-Yeul (Department of Nuclear Medicine, Channam University Hospital) ;
  • Lee, Chong-Bin (Department of Biology, Channam National University)
  • 채기문 (전남대학교병원 핵의학과) ;
  • 최근희 (전남대학교병원 핵의학과) ;
  • 김영호 (전남대학교병원 핵의학과) ;
  • 김광윤 (전남대학교병원 핵의학과) ;
  • 범희승 (전남대학교병원 핵의학과) ;
  • 김지열 (전남대학교병원 핵의학과) ;
  • 이종빈 (전남대학교 자연과학대학 생물학과)
  • Published : 1997.03.30

Abstract

Radiation protection by post-irradiation injection of the ginseng extract in mice was studied. Male ICR mice, 7 weeks old, were orally injected with ginseng extrat(100mg/kg) for 10 days, and with physiologocal saline as the control. Immediately after final injection, mice were whole body irradiated with 5.08Gy(Cs-137 ${\gamma}$-ray, central dose rate : 654Gy/h) which induced Bone marrow death. At 24h after irradiation, micronucleus test and metaphase analysis in bone-marrow were carried, blood cell were counted and the survival rate were carried for 30 days after the irradiation. Stimulated recovery by the extract was observed in thrombocyte count, but that phenomenom was not showed in the erythrocyte and leucocyte counts. The 30-day survival ratio was 5% and 65% for the control and experimental group. Frequencies of micronuclei per 1000 polychromatic erythrocytes were 79.5${\pm}$1.5 in experimental group, 185.9${\pm}$35.8 in control. And Abnormal chromosomes per 50 metaphases were 112 in experimental group and 143 in control.