The Effect of Exam Stress and Vitamin B Complex on Plasma ACTH, Cortisol and Prolactin Level

시험 스트레스와 Vitamin B 복합제가 혈장 ACTH, Cortisol 및 Prolactin치에 미치는 영향

  • Koh, Kyung-Bong (Department of Psychiatry, Yonsei University College of Medicine)
  • 고경봉 (연세대학교 의과대학 정신과학교실)
  • Published : 1996.12.15


The study was designed to find out the effect of exam stress and vitamin B complex on hormones such as plasma ACTH, cortisol and prolactin. 21 medical students completed the whole period of the study. Global assessment of recent stress(GARS) scale and SCL-90-R were used to measure stress perception and psychopathology. Radioimmunoassay was used to assess plasma ACTH, cortisol and prolactin. Plasma ACTH level was significantly higher 2 weeks prior to examination and exam period, respectively, than 4 weeks prior to the exam. However, there were no significant differences in plasma cortisol and prolactin level among the three periods. No significant differences were also found in plasma ACTH, cortisol and prolactin level between vitamin and non-vitamin groups during each period. Scores of stress perception in economic area significantly had a positive correlation with plasma ACTH and prolactin level, respectively, 2 weeks prior to the exam. In psychopathology, scores of hostility subscale significantly had a Positive correlation with plasma ACTH level. There were no significant differences in change of each of the hormones over time as well as between vitamin and non-vitamin groups. In conclusion, it was found that ACTH was more sensitive to exam stress than cortisol or prolactin, and that vitamin B complex had no significant influence on ACTH, cortisol and prolactin level.