Antibacterial Activity by Chitosan Derivatives with Quaternary Ammonium Salt

4차 암모늄기를 가진 키토산 유도체의 항균성

  • Kim, C.H. (Dept. of Industrial Chemistry, College of Engineering, Hanyang University) ;
  • Choi, Y.S. (Dept. of Industrial Chemistry, College of Engineering, Hanyang University) ;
  • Choi, K.S. (Dept. of Industrial Chemistry, College of Engineering, Hanyang University)
  • 김천호 (한양대학교 공과대학 공업화학과) ;
  • 최영선 (한양대학교 공과대학 공업화학과) ;
  • 최규석 (한양대학교 공과대학 공업화학과)
  • Received : 1996.06.14
  • Accepted : 1996.07.22
  • Published : 1996.10.10

Abstract

Chitosan is the deacetylation product of chitin. Chitosan was converted to N-alkyl chitosan derivatives using proper aldehyde having different alkyl chains, then chitosan derivatives with quaternary ammonium salt were producted by quaternization with methyl iodide. Their antibacterial activities aganst S. aureus(ATCC 6538P) and E. coli (ATCC 14339), gram-positive bacteria and gram-negative bacteria, respectively, as introduced alkyl length were evaluated by shake flask method using colony count. The antibacteiral activity was found to be increased as alkyl chains. hydrophobic goups. These antibacterial agents were more active against S. aureus than E. coli. It may be due to the different of structure of cytoplasmic membrane.

Keywords

Acknowledgement

Supported by : 교육부

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