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INTRACEREBROVENTRICULARLY ADMINISTERED PHENYLALANINE AND TYROSINE: EFFECTS ON FEEDING BEHAVIOUR AND NOREPINEPHRINE CONCENTRATIONS OF SPECIFIC BRAIN SITES IN THE CHICKEN

  • Choi, Y.-H. (Laboratory of Animal Nutrition, School of Agriculture, Nagoya University) ;
  • Furuse, M. (Laboratory of Animal Nutrition, School of Agriculture, Nagoya University) ;
  • Okumura, J. (Laboratory of Animal Nutrition, School of Agriculture, Nagoya University) ;
  • Shimoyama, Y. (College of Agriculture, Utsunomiya University) ;
  • Sugahara, K. (College of Agriculture, Utsunomiya University) ;
  • Denbow, D.M. (Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University)
  • Received : 1995.08.12
  • Accepted : 1995.11.07
  • Published : 1996.06.01

Abstract

A study was carried out to investigate the action of central L-pheylalanine (Phe) and L-tyrosine (Tyr) on food intake of the chicken. In the first trial, Phe ($200{\mu}g/10{\mu}l$) or saline was acutely administered into the right lateral ventricle (i.c.v.) of chickens (5 birds per each group). Birds (4 birds per each group) were administered with the i.c.v. Tyr ($200{\mu}g/10{\mu}l$) or saline in the second trial. The brains of the birds were removed for catecholamine assy 30 min postadministration. Catecholamine concentrations were measured at specific sites of the brain (LH: lateral hypothalamus, PVN: paraventricular nucleus, and VMH: ventromedial hypothalamus). No significant effect of amino acids on the concentration of norepinephrine of brain sites investigated was detected. Food intake and rectal body temperature were also monitored for 6 h after central administrations of Phe, Tyr or saline (5 birds per each group). Both Phe and Tyr, up to $1mg/10{\mu}l$, failed to modulate food intake or rectal body temperature.

Keywords

Phenylalanine;Tyrosine;Food Intake;Chicken;I.C.V. Injection

Acknowledgement

Supported by : Ministry of Education, Science and Culture, Japan, Kyowa Hakko Kogyo Co. Ltd.

Cited by

  1. Ghrelin Activates Behavior of Neonatal Chicks in a Short Period of Post-Intracerebroventricular Injection vol.22, pp.1, 2002, https://doi.org/10.1080/09712119.2002.9706376
  2. Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks vol.43, pp.1, 2002, https://doi.org/10.1080/00071660120109971