Plasma Antioxidant Status and Platelet Antionxidative Enzyme Activities in Patients of Ischemic Heart Disease

허혈성심질환에서의 항산화영양소 상태와 혈소판 항산화계효소 활성에 관한 연구

  • 최영선 (대구대학교 식품영양학과)
  • Published : 1996.03.01

Abstract

To investigate antioxidant status and platelet antioxidative enzyme activity in patients with ischemic heart disease, 36 male patients admitted to Kyungpook National University Hospital from June to December 1994 were compared to 36 healthy male control subjects. The percentages of heavy smoking and nonexercise were significantly higher in the patient group compared to the control, but the drinking status was not significantly different between groups. Food habit and food frequency scores were significantly lower in patients than in control subjects. Plasma retinol levels tended to be lower in the patient group, and plasma $\alpha$-tocopherol and $\beta$-carotene levels were not different between groups. There was no difference in the level of plasma thiobarbituric acid reactive substances(TBARS) and in the activities of platelet glutathione peroxidase and catalase. Our results indicate that oxidative stress, which is reflected by the plasma levels of antioxidants and TBARS, did not increase in the patients with ischemic heart disease, and the long-term effects due to smoking, poor food habit and other life styles could possibly contribute to the onset of the disease.

References

  1. 사망통계연보 경제기획원 조사 통계국
  2. 피보험자 건강진단결과중 질환유병율 의료보험관리공단
  3. Diet, nutrition, and the prevention of chronic diseases Report of a WHO Study Group
  4. British Med Bulletin v.49 Lipid peroxidation and its role in atherosclerosis Esterbauer,H.;Waeg,G.;Puhl,H.
  5. Ann Med v.23 Effects of antioxidants on oxidative modification of LDI Esterbauer H.;Puhl H.;Dieber Rotheneder M.;Waeg G.;Rabl H.
  6. Arterioscler Thromb v.12 Supplementation with vitamin E but not β-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro Princen,H.M.G.;Van,Poppel,G.;Vogelezang,C.;Buytenhek,R.;Kok,F.J.
  7. J Lipid Res v.32 Effect of oral supplementation with d-alphatocopherol on the vitamin E content of human low density lipoprotein and resistance to oxidation Dieber­Rotheneder,M.;Puhl,H.;Waeg,G.;Striegl,G.;Esterbauer,H.
  8. Clin Chim Acta v.204 Predisposition to LDL oxidation during copper-catalyzed oxidative modification and its relation to α-tocopherol content in humans Cominacini,L.;Garbin,U.;Cenci,B.;Davoil,A.;Pasini,C.;Ratti,E.;Gaviraghi,G.;Lo-Cascio,V.;Pastorino,A.M.
  9. J Am College Nutr v.12 Antioxidants and cardiovascular disease : A review Manson,J.E.;Gaziano,J.M.;Jonas,M.A.;Hennekens,C.H.
  10. Am J Clin Nutr v.62 no.Sup. Epidemiologic evidence for vitamin E in prevention of cardiovascular disease Stampfer,M.J.;Rimm,E.B.
  11. Prog Cardiovas Dis v.28 The oxygen free radical system : A fundamental mechanism in the production of myocardial necrosis Thompson,J.A.;Hess,M.L.
  12. Free Rad Biol Med v.4 Lipid peroxidation and endothelial injury : Implications in atherosclerosis Henning,B.;Chow,C.K.
  13. Prostaglandins Leukotriene Med v.21 Vitamin E exerts antiaggregatory effects without inhibiting the enzymes of the arachidonic acid cascade in platelets Srivastava,K.C.
  14. Am J Clin Nutr v.53 Effects of antioxidant supplementation on platelet function; randomized pairmatched, placebo-controlled, double-blind trial in men with low actioxidants status Salonen,J.T.;Salonen,R.;Seppanen,K.
  15. Atherosclerosis v.100 Changes in actioxidant enzymes activities, Aggregability and malonyldialdehyde concentration in blood platelets from patients with coronary heart disease Buczynski,A.;Wachowicz,K.;Kedziora­Kornaatowska,K.;Tkaczewski,W.;Kedziora,J.
  16. 영양학실험 백태홍;전세영;김천호
  17. 국민영양 no.7;8 심장 순환기계 질환 및 비만의 영양상담 자료 분석 대한영양사회
  18. Clin Chem v.18 Estimation of concentration of low density lipoprotein cholesterol in plasma witheout use of ultracentrifuge Friedewald,W.T.;Levy,R.I.;Fredrickson,D.S.
  19. Biochem Med v.15 A simple fluorometric assay for lipoperoxide in blood plasma Yagi,K.
  20. Am J Clin Nutr v.32 Simultaneous determination of alpha-tocopherol and retinol in plasma or red blood cells by high pressure liquid chromatography Bieri,G.;Tolliver,J.J.;Catignani,G.L.
  21. 한국영양학회지 v.22 카로텐 공급이 정상식이 여성과 채식주의 여성의 혈청 카로첸 및 레티놀 수준에 미치는 영향 김혜영
  22. J Nutr v.113 Platelet glutathione peroxidase activity as an index of selenium status in rats Levander,O.A.;DeLoach,D.P.;Morris,V.C.;Moser,P.B.
  23. Methods of Enzymatic Analysis(2nd ed.) Luck,H.Catalase;Bergmeyer,H.U.(ed.)
  24. J Biol Chem v.193 Protein measurement with the Folin phenol reagent Lowry,O.H.;Rosenbrough,W.J.;Farr,A.L.;Randall,R.J.
  25. 한국영양학회지 v.28 no.1 대구 지역 중년 남성의 혈중 항산화성 영양소와 지질상태에 관한 연구 조성희;이옥주;임정교;최영선;유리나;박의현
  26. Eur J Clin Nutr v.49 Plasma concentration of carotenoids and antioxidant vitamins in Scottish males : influences of smoking Ross,M.A.;Grosley,L.K.;Brown,K.M.;Duthie,S.J.;Collins,A.C.;Arthur,J.R.;Duthie,G.G.
  27. Am J Epidemiol v.127 The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alphatocopherol levels Stryker,W.S.;Kaplan,L.A.;Stein,E.A.;Stampfer,M.J.;Sober,A.;Willett,W.C.
  28. Am J clin Nutr v.60 Effects of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators Lecomte,E.;Herbeth,B.;Pirollet,P.;Chancerelle,Y.;Arnaud,J.;Musse,N.;Paille,F.;Siest,G.;Artur,Y.
  29. 한국영양학회지 v.28 no.8 대구 지역 중년 남성의 혈청지질과 혈청 과산화지질의 관련 인자 연구 최영선;이옥주;조성희;박의현;임정교;권순자
  30. Am J Clin Nutr v.60 Selenium status, fatty acids, vitamins A and E, and aging : the Nove study Olivieri,O.;Stanzial,A.M.;Girelli,D.;Trevisan,M.T.;Guarini,P.;Terzi,M.;Caffi,S.;Fontana,F.;Casaril,M.;Ferrari,S.;Corrocher,R.
  31. Am J Clin Nutr v.59 no.sup. Diet and coronary heart disease : beyond dietary fats and low-density-lipoprotein cholesterol Fraser,G.E.
  32. Am J Clin Nutr v.57 Dietary diversity and subsequent mortality in the first national health and nutrition examination survey epidemiologic follow-up study Kant,A.K.;Schatzkin,A.;Harris,T.B.;Ziegler,R.G.;Blocj,G.
  33. 한국지질학회지 v.2 한국정상성인의 혈청지질농도, 체질량지수, 혈압 및 식습관과 일상생활 습관과의 관계에 관한 연구. - 혈청 triglyderide를 중심으로 -. 이양자;신현아;이기열;박연희;이종순
  34. Circulation v.40 no.Sup.4 The role of lipids in acute myocardial infarction Fredrickson,D.S.
  35. 순환기 v.23 관상동맥질환에서 혈중 지질 및 lipoprotein(a)에 관한 연구 박창규;김영훈;서홍석;심완주;오동주;노영무;박정의
  36. 순환기 v.21 허혈성심장병의 위험인자로서의 혈청지질분획 및 apolipoprotein 채성철;전재은;박의현;김정철;정태호
  37. 순환기 v.16 한국인 관상동맥질 에서 혈청지단백의 변화에 관한 연구 박금수;이응구;조성연;심원흠;정남식;장양수;최경훈
  38. 한국지질학회지 v.1 no.1 한국인의 죽상 경화증이 지단백 (Lp(a))의 정상기준치 및 관상동맥질환 발병의 위험인자로서 LP(a)의 의의에 관한 연구 김진규;송정한;이명묵;박영배;정홍금;채범석;김상인
  39. 한국지질학회지 v.1 no.1 Lipoprotein (a)의 농도에 영향을 미치는 질환 및 인자에 관한 연구 김치정;장학철;김한수;민용기;신현호;한인권
  40. Brit Med Bulletin v.49 Prospects for the prevention of free radical disease, regardings cancer and cardiovascular disease Gey,K.F.
  41. 대한암학회지 v.24 no.3 혈청 retinoids, β-carotene 및 α-tocopherol과 암과의 관계 임경진;이양자;이기열;김병수;노재경;박계숙
  42. β-carotene and Human Health, Prodeedings of The International Symposium Studies on β-carotene and cancer in Korea 이양자;Yang Cha Lee(ed.);In Suh Park(ed.);Byung Soo Kim(ed.)
  43. Am J Epidemiol v.127 Serum levels of retinol. beta-carotene, and alpha-tocopherol in older adults Comstock,G.W.;Menkes,M.S.;Schober,S.E.;VuilleumierJ.­P.;Helsing,K.J.
  44. Eur J Clin Nutr v.43 Dietary intake and other determinants of blood vitamins in an elderly population Herbeth,B.;Chavance,M.;Musse,N.;Mejean,L.;Vernhes,G.
  45. Am J Cardiol v.64 Changes in plasma vitamin levels in the first 48 hours after onset of acute myocardial infarction Scragg,R.;Jackson,R.;Holdaway,I.;Woollard,E.
  46. Lancet v.339 Susceptibility to low density lipoprotein oxidation and coronary atherosclerosis in man Regnstrom,J.;Nilsson,J.;Tornvall,P.;Landou,C.;Hamsten,A.
  47. Free Rad Biol Med v.13 The role of lipid peroxidation and antioxidants in oxidative modification of LDL Esterbauer,H.;Gebicki,J.;Puhl,H.;Jurgens,G.
  48. Am J Clin Nutr v.57 no.sup. Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants : an epidemiological update with special attention to carotene and vitamin C Gey,K.F.;Moser,U.K.;Jordan,P.;Stahelin,H.B.;Eichholzer,M.;Ludin,E.
  49. N Engl J Med v.328 A prospective study of vitamin E consumption and risk of coronary heart disease in women Stampfer,M.J.;Hennekens,F.E.;Manson,J.E.;Colditz,G.A.;Rosner,B.;Willett,W.C.
  50. N Engl J Med v.328 Vitamin E consumption and the risk of coronary heart disease in men Rimm,E.B.;Stampfer,M.J.;Ascherio,A.;Giovannucci,E.;Colditz,G.A.;Willett,W.C.
  51. Am J Clin Nutr v.62 no.sup. Antioxidant vitamin-cardiovascular disease hypothesis in still promising, but still unproven : the need for randomized trials Hennekens,C.H.;Gaziano,J.M.;Manson,J.E.;Buring J.
  52. Atherosclerosis v.81 Vitamin E content and low density lipoprotein oxidizability induced by free radicals Babiy,A.V.;Gebicki,J.M.;Sullivan,D.R.
  53. J Clin Pathol v.37 Selenium and vitamin E in relation to risk factors for coronary heart disease Ellis,N.;Lloyd,B.;Clayton,B.E.
  54. Am J Clin Nutr v.60 Vitamin E supplementation supresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipprotein concentrations remain unchanged Brown,K.M.;Morrice,P.C.;Duthie,G.G.
  55. Am J Clin Nutr v.61 Chronic intake of pharmacological doses of vitamin E might be useful in the therapy of elderly patients with coronary heart disease Paolisso,G.;Gambardella,A.;Giugliano,D.;Galzerano,D.;Amato,L.;Volpe,C.;Balbi,V.;Varricchio,M.;D'Onofrio,F.