Effects of the Anabolic Steroid, Nandrolone Pheylpropionate, on Growth and Muscle Protein Metabolism in ACTH-treated Rats

ACTH를 투여한 흰쥐에서 아나보릭스테로이드인 Nandrolone Phenylpropionate가 성장한 근육단백질 대사에 미치는 영향

  • 주종재 (군산대학교 식품영양학과)
  • Published : 1996.10.01


The effects of an anabolic steroid, nandrolone phenylpropionate(NPP), on body weight gain and body protein, and muscle protein metabolism were inestigated in adrenocorticotrophic hormone(ACTH)-treated male and female rats. Daily injections of 100ug/day of ACTH for 7-8 days caused a cessation of growth in females and a net loss of body weight in males which were associated with significant reductions in body protein content. However, food intake was not affected by ACTH in either sex. The weight, protein content and fractional rate of protein synthesis, measured in vivo, of gastrocnemius muscle were all significantly reduced in both sexes. NPP at a dose of 4mg/kg body weight prevented the reduction in body weight gain in ACTH-treate females but not in males. However, boy protein content was increased by NPP in both sexes which was associated with increases in the weight, protein content and fractional rate of protein synthesis of gastrocnemius muscle. ACTH treatment caused a marked increase in plasma concentrations of corticosterone in both sexes. NPP suppressed much of the increases in corticosterone concentrations in both sexes. The results of the present study suggest that NPP exerts at least part of its anabolic effect by reducing plasma concentrations of catabolic glucocorticoid hormones, through suppressing the response of the adrenals to ACTH.


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