Mechanism of Radioresistance Induced by Low-Dose Irradiation

저준위 방사선에 의해 유도된 방사선저항의 기전

  • Park, Sang-Hee (Dept. of Biology, Seoul Women's University) ;
  • Cho, Chul-Koo (Dept. of Therapeutic Radiology, Korea Cancer Center Hospital) ;
  • Yoo, Seong-Yul (Dept. of Therapeutic Radiology, Korea Cancer Center Hospital) ;
  • Lee, Yeon-Hee (Dept. of Biology, Seoul Women's University)
  • 박상희 (서울여자대학교 생물학과) ;
  • 조철구 (원자력병원 치료방사선과) ;
  • 류성렬 (원자력병원 치료방사선과) ;
  • 이연희 (서울여자대학교 생물학과)
  • Published : 1996.06.30

Abstract

After high-dose irradiation(8 Gy). the viability of lymphocyte with a prior low-dose irradiation was 3.7-fold higher than that without a prior low-dose irradiation The viability could be increased by the reduction of oxygen radicals or the removal of damaged molecules-DNA, protein. lipid membrane. or the removal of damaged cells. In this paper. we studied the radioresistance mechanism in lymphocytes and lymphoma cells by examining the activities of radical scavengers(catalase. peroxidase, superoxide dismutase, and glucose-6-phosphate dehydrogenase), and a radical protector(glutathione). Different enzymes were induced in lymphocyte and lymphoma with low-dose irradiation. The activity of peroxidase increased most(133.3%) in lymphoma while the enzymes increased most in lymphocyte were superoxide dismutase (138.5%), glucose-6-phosphate dehydrogenase (122.4%) and glutathione(120.8%). The activities of these enzymes were highest when the interval was 7 hours between low-dose and high-dose irradiation.