Synthesis of Some Quinoxaline Derivatives Containing Indoline-2,3-dione or Thiazolidinone Residue as Potential Antimicrobial Agents

  • Gendy, Adel-A. El (Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt) ;
  • Meligie, Salwa-El (Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt) ;
  • Afaf-K. El-Ansary (Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt) ;
  • Aly-M. Anmedy (Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt)
  • Published : 1995.02.01

Abstract

The synthesis of osme quinoxaline derivatives containing indoline-2, 3-dione or thiazolidlinone residue is described. The synthesized derivatives were sureened in vitro for their growth inhibitory activity against six species of bacteria, viz. Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Mycobacterium semegmatils. Most of the compounds exhibited antimicrobial activity especially those having indoline-2, 3-dione moiety.