Effects of G009 on Chemical-Induced Liver Damage in Rats

G009의 간 보호작용에 관한 연구

  • Lee, Joo-Young (College of Pharmacy, Seoul National University) ;
  • Park, Ki-Sook (College of Pharmacy, Seoul National University) ;
  • Chung, Jin-Ho (College of Pharmacy, Seoul National University) ;
  • Cho, Mee-Jung (College of Pharmacy, Seoul National University) ;
  • Ko, Kwang-Ho (College of Pharmacy, Seoul National University) ;
  • Lee, Jun-Woo (Central Research Institute of Il Yang Pharm Co.) ;
  • Jeong, Hoon (Central Research Institute of Il Yang Pharm Co.) ;
  • Lee, Seung-Yong (Central Research Institute of Il Yang Pharm Co.)
  • Published : 1994.08.01

Abstract

The present study was performed to determine the protective effect of G009 on liver damage induced bv ethanol $CCl_4$ and thioacetamide in rats. In acute fatty liver animal model induced by ethanol, triglyceride accumulation was markedly decreased to the normal control level by 25 mg/kg G009 treatment. In addition, G009 significantly reduced serum ALT and AST levels in $CCl_4$-induced acute hepatitis animals. Treatment of G009 to the acute hepatitis rats induced by thioacetamide resulted in a dose dependent reduction of serum ALT level as well as AST level up to the normal control level. These protective effects of G009 were confirmed by histological examinations of the liver. These results suggested that G009 could be effective for the protection from the liver damage induced by ethanol, $CCl_4$and thioacetamide.

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