Prediction of Oxygen Transfer Rate During Sisomicin Fermentation Employing Air Lift Fermentor

Air Lift Fermentor에서 Sisomicin 발효시에 발효유사액을 이용한 산소전달속도 예측

  • 김성룡 (연세대학교 공과대학 식품생물공학과 및 생물산업소재연구센터) ;
  • 신철수 (연세대학교 공과대학 식품생물공학과 및 생물산업소재연구센터)
  • Published : 1994.12.01


In order to predict gas hold-up and oxygen transfer rate during sisomicin fermentation employing air lift fermentor, simulated media similar to fermentation broths in rheological proper- ties were prepared and used. Rheological properties of fermentation broths from 40 hours and 60 hours of cultivation were analyzed by applying to Power's Law equation. Regardless of addition and no addition of MgSO$_{4}$, the tendencies, that n value was decreased and K value was increased as aeration rate was increased, were shown. Simulated media of twelve different fermentation broths were formulated in a range of 0.7 to 2.1% CMC, and the values of gas hold-up and k$_{L}$a depending on superficial air velocity were measured using these simulated media. And the relation- ships, $\varepsilon$=$\alpha$U$_{Gr}$$\beta$, K$_{L}$a=$\gamma$U$_{Gr}$$\delta$ were obtained, and these equations are thought to be used to predict the values of gas hold-up and k$_{L}$a during fermentation.


Sisomicin;fermentation;air lift fermentor;oxygen transfer rate


  1. M.S. Thesis Characteristics of Sisomicin Fermentation Using Air Lift Fermentor Kim,S.Y.
  2. Biotechnol. Bioeng. v.23 Influence of engineering variables upon the morphology of filamentous molds van Suijdam,C.;B.Metz
  3. Appl. Microbiol. Biotechnol. v.28 Liberation of sisomicin from cells by sodium chloride Shin,C.S.;B.W.Ahn;S.H.Lee;S.U.Kim;S.H.Bok
  4. Air Lift Bioreactors Chisti,M.Y.
  5. Microbiological Assay Hewitt,W.
  6. Kor. J. Appl. Microbiol. Bioeng. v.17 Effect of mineral salts on the improvements of sisomicin yield Shin,C.S.;S.H.Han;S.H.Lee
  7. Fermentation and Enzyme Technology Wang,D.I.C.;C.L.Cooney;A.L.Demain;P.Dunnil;A.E.Humphery;M.D.Lilly
  8. M.S. Thesis Analysis of the Effects of Magnesium Sulfare on the Improvement of Sisomicin Yield Han,S.H.
  9. Kor. J. Appl. Microbiol. Biotechnol. v.20 Effect of magnesium sulfate on sisomicin fermentation Han,S.H.;C.S.Shin
  10. Advances in Biochemical Engineering v.11 The rheology of mould suspensions Metz,B.;N.W.F.Kossen;J.C.Van Suijdam;T.K.Ghose(ed.);A.Fiechter(ed.);N.Blakebrough(ed.)
  11. Biotechnol. Lett. v.16 Characteristics of sisomicin fermentation supplemented with MgSO₄in stirred and air lift fermentors Shin,C.S.;S.Y.Kim;J.Y.Yu