Rubiginone $B_2$, Isotetracenone Antibiotics which Reverses Multidrug-Resistance in KB Tumor Cells

KB 암세포에 효과있는 Streptomyces plicotosporus가 생산하는 항암증강물질 Rubiginone $B_2$ 에 관한 연구

  • ;
  • ;
  • Seto Haruo
  • 하상철 (한국과학기술연구원 유전공학연구소) ;
  • 홍순덕 (경북대학교 자연과학대학 미생물학과) ;
  • Published : 1994.10.01

Abstract

Antibiotic HS-2 was purified from the culture broth of Streptomyces plicatosporus which was isolated from soil, by solvent extraction, silica gel column chromatography and gel filtration. Through the analysis of UV, $^{1}$H-NMR, $^{13}$C-NMR spectrum, HS-2 was identified as rubiginone B$_{2}$. It was confirmed that HS-2 enhanced the cytotoxicity of colchicine against multidrug-resistant tumor cells.

Keywords

KB-C2;multidrug-resistance;rubiginone B2;Streptomyces plicatosporus

References

  1. J. Biol. Chem. v.261 Multiple drug-resistant human KB carcinoma cells indepenently selected for high level resistant to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins Shen,D.;C.Cardareul;J.Hwang;M.Cornwell;N.Richert;S.Ishii;I.Pastan;M.M.Gottesman
  2. 동경대학교 박사논문 신규 isotetracenone계 항생물질 hatomarubigin에 관한 연구 하상철
  3. Biochem. Biophys. Acta. v.948 Mechanism of multidrug resistance Bradley,G.;P.F.Jurnaka;V.Ling
  4. Jpn. J. Cancer Res. v.79 Mechanism of multidrug resistance and implications for therapy Tsuruo,T.
  5. J. Antibiot. v.43 Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity Oka,M.;H.Kamel;Y.Hamagishi;K.Tomita;T.Miyaki;M.Konishi;T.Oki
  6. J. Antibiot. v.38 Studies on the isotetracenone antibiotics;Ⅰ.capoamycin, a new antitumor antibiotic Hayakawa,Y.;T.Iwakiri;K.Imamura;H.Seto;N.Otake
  7. J. Antibiot. v.40 Studies on the isotetracenone antibiotics;Ⅲ.a new isotetracenone antibiotic, grincamycin Hayakawa,Y.;T.Iwakiri;K.Imamura;H.Seto;N.Otake
  8. J. Antibiot. v.38 Studies on the isotetracenone antibiotics;Ⅱ.kerriamycins A,B and C, new antitumor antibitics Hayakawa,Y.;T.Iwakiri;K.Imamura;H.Seto;N.Otake