Preparation of $Ginsenoside-Rh_2$ from Dammarane Saponins of Panax ginseng Leaves

인삼잎의 Dammarane계 사포닌으로부터 $Ginsenoside-Rh_2$의 제조

  • 차배천 (상지대학교 농과대학) ;
  • 이상국 ((주)대웅제약 중앙연구소)
  • Published : 1994.08.30

Abstract

The genuine aglycone, 20(S)-protopanaxadiol, obtained from the leaves of Panax ginseng as a result of direct alkaline treatment was isolated and characterized by spectroscopic evidences. The study on the yield of genuine aglycone which is produced from the treatment of some kinds of alkali was carried out. $Ginsenoside-Rh_2$ was synthesized by conjugation of 2,3,4,6-tetra-O-acetyl-${\alpha}$-D-glucopyranosyl bromide to 20(S)-protopanaxadiol in the presence of silver carbonate and cadmium cabonate. The preparation of $ginsenoside-Rh_2$ by this method is a new one which the yield of this saponin can be improved in the mild condition.