The Removal of Contaminated Radiostrontium from Mice by Water Soluble Chitosan

카이토산을 이용한 방사성스트론튬 오염의 치료

  • Bom, Hee-Seung (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Kim, Kwang-Yoon (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Yang, Kwang-Hee (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Chae, Ki-Moon (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Choi, Keun-Hee (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Song, Ho-Chun (Department of Nuclear Medicine, Chonnam University Hospital) ;
  • Kim, Ji-Yeul (Department of Nuclear Medicine, Chonnam University Hospital)
  • 범희승 (전남대학교병원 핵의학과) ;
  • 김광윤 (전남대학교병원 핵의학과) ;
  • 양광희 (전남대학교병원 핵의학과) ;
  • 채기문 (전남대학교병원 핵의학과) ;
  • 최근희 (전남대학교병원 핵의학과) ;
  • 송호천 (전남대학교병원 핵의학과) ;
  • 김지열 (전남대학교병원 핵의학과)
  • Published : 1994.12.30

Abstract

The aim of the present study was to elucidate the effect of the water soluble chitosans on the removal of contaminated radiostrontium (Sr-85) from the bone of mice. The remaining radioactivities in intravenously injected controls(group 1) were higher than in intraperitoneally injected controls (group 4, P<0.01). The % retention at day 5 were $57.7{\pm}1.9%,\;54.4{\pm}1.2%$, respectively. Single intravenous injection of 0.3% water soluble chitosan and continuous oral ingestion of 10% water soluble chitosan for 15 days were' ineffective on the removal of contaminated radiostrontiums. Multiple intravenous or intraperitoneal injections of water soluble chitosan effectively removed contaminated radiostrontiums(P<0.01 vs controls). In conclusion, water soluble chitosan might remove once incorporated radiostrontium from bones of mice. Further studies were needed to elucidate the mechanism of the removal.