Intrafamilial Transmission of HCV: Comparison with HBV

HCV의 가족내 감염양상: HBV의 가족내 감염양상과 비교

  • Lee, Heon-Ju (Department of Internal Medicine College of Medicine, Yeungnam University)
  • 이헌주 (영남대학교 의과대학 내과학교실)
  • Published : 1992.12.30


Among 85 patients with anti-HCV positive chronic liver disease, only 21.2% have past history of blood transfusion and over half the cases, they do not have any suspicious risk factors for HCV infection, 3 of 85 families show anti-HCV positive family members. On the other hand, 40 of 60 patients with HBsAg positive chronic liver disease show HBsAg positive family members. In Korea, HBV is transmitted mainly through vertical and intrafamilial infection but HCV disease might be rather horizontal and sporadic than vertical. To define the evident source of infection in sporadic hepatitis C, first of all, simple test with high sensitivity and specificity for diagnosis of HCV infection would be needed.