Anticancer Activities of the Extract from the Mycelia of Coriolus versicolor

운지버섯 균사체 추출물의 항암효과에 관한 연구

  • 이병우 (오뚜기 중앙연구소) ;
  • 이명섭 (건국대학교 동물자원연구센터) ;
  • 박기문 (오뚜기 중앙연구소) ;
  • 김창한 (건국대학교 동물자원연구센터) ;
  • 안평옥 (오뚜기 중앙연구소) ;
  • 최춘언 (오뚜기 중앙연구소)
  • Published : 1992.06.01

Abstract

An anticancer substance was prepared by ethanol precipitation of the hot water extract of culture mycelia of Conolus versicolor KFCC 30388. After 6 days of fermentation, the mycelia growth reached the peak and reducing sugar consumed almost all. HTCFA method has been employed for three human cancer cell lines, Hep-2(larynx cell), A-427 and Calu-3 (lung cell). Anticancer activities in A-427 and Calu-3 were 8.4 and 9.8% survival rate, respectively. The chemical analysis of the extract from the mycelia showed 42.2% of polysaccharide and 10.5% of protein. The polysaccharide consisted of five kinds of monosaccharides, L-glucose, D-glucose, galactose, mannose and xylose.

Keywords

Anticancer substance;HTCFA;mycelia;Coriolus versicolor