Effect of Steram Distillate from Some Medicinal Plants on Acetylcholinesterase Activity Following Intoxication by Organophosphate Pesticides in Animals

수종 생약 수증기 증류물이 유기인제 농약에 의하여 저해된 Acetylcholinesterase 활성에 미치는 효과

  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Song, Young-Jin (Natural Products Research Institute, Seoul National University) ;
  • Kim, Oon-Ja (Natural Products Research Institute, Seoul National University)
  • 신국현 (서울대학교 천연물과학연구소) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 송영진 (서울대학교 천연물과학연구소) ;
  • 김운자 (서울대학교 천연물과학연구소)
  • Published : 1992.06.30

Abstract

The acute toxicity and the effect of steam distillate obtained from several plant mixtures (G-3) on the reactivation of brain, lung, and blood acetylcholinesterase (AChE) activity, and recovery from other toxic symptoms following intoxication by organophosphate pesticides were investigated in mice and mudfish. Administration of G-3 $(50{\sim}100\;ml/kg,\;i.p.)$ immediately or 30 min prior to Diazinon or Sumithion treatments, respectively, resulted in a significant reactivation of AChE activity in brain, lung, and blood, their potencies being almost equipotent to those of 2-PAM, one of well-known antidotes. G-3 itself exhibited almost no acute toxicity even at the highest dose employed, and without effect on the inhibition of hepatic drug metabolism function following organophosphate administrations. G-3 showed a significant diminution of the death rate in mudfish as well as in mice intoxicated by Diazinon.