Synthesis of Permeability-Controllable Polymerized Vesicles

투과도 조절용 고분자화된 Vesicles의 합성

  • Shin, Jae-Sup (Department of Chemistry, Chungbuk National University)
  • 신재섭 (충북대학교 자연과학대학 화학과)
  • Received : 1991.02.25
  • Published : 1991.03.25

Abstract

A lipid containing a 1, 2-dithiolane group was synthesized, and polymerized vesicle was prepared from the vesicle of this lipid by ring-opening polymerization. Reaction rate of the polymerization was monitored by UV absorption, and the results showed that it followed the first order kinetics and the rate constant $3.84{\times}10^{-2}min^{-1}$. Permeation rate of sucrose through the polymerized vesicle was $4.7{\times}10^{-8}cm\;hr^{-1}$, which is 1.5 times lower than that of monomeric analog.

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Acknowledgement

Supported by : 한국학술진흥재단