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RESTRICTION BY MOTHERWORT (Leonurus sibiricus L) OF LACTATION SUPPRESSED BY PREGNANCY-DEPENDENT MAMMARY TUMORS IN GR/A MICE

  • Nagasawa, H. (Experimental Animal Research Laboratory, Meiji University) ;
  • Suzuki, M. (Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida) ;
  • Inatomi, H. (Laboratory of Natural Product Chemistry, Meiji University) ;
  • Hibino, A. (Laboratory of Natural Product Chemistry, Meiji University) ;
  • Yamamuro, Y. (Department of Animal Breeding, College of Agriculture and Veterinary Medicine, Nihon University) ;
  • Sensui, N. (Department of Animal Breeding, College of Agriculture and Veterinary Medicine, Nihon University)
  • Received : 1990.04.23
  • Accepted : 1990.11.04
  • Published : 1991.03.01

Abstract

As a possible step to evaluate in the mammary gland the role of motherwort (Leonurus sibiricus L), a representative medicinal plant used traditionally for the therapy of gynecologic diseases, the effects of the agent on lactation which was suppressed by preganacy-dependent mammary tumors (PDMT) were studied in GR/A mice. Beginning the day of placing with males at 45-50 days of age, female mice were given 60% methanol-extract of the aerial part of motherwort as drinking water at the concentration of 0.5% throughout the experiment. Mice developing PDMT during pregnancy [PDMT(+)] and given motherwort were similar to mice developing no PDMT [PDMT(_)] with or without motherwort treatment and were significantly higher than PDMT(+) mice given tap water in litter growth and mammary RNA/DMA ratio on day 12 of the 2nd lactation. Mammary DNA and RNA contents were also elevated by motherwort in PDMT(+) mice. The results suggest that motherwort can ameliorate lactation suppressed by PDMT through its stimulation of both growth and function of the mammary glands.

Keywords

GR/A;Lactation;Motherwort;Mice;Pregnancy-Dependent Mammary Tumors