Drug Release Characteristics of Crosslinked Poly(alkylene oxide) Hydrogels

가교된 폴리 알킬렌 옥사이드 하이드로겔의 약물방출 특성

  • 김신정 (이화여자대학교 약학대학) ;
  • 이승진 (이화여자대학교 약학대학)
  • Published : 1991.06.20


Polyethylene glycol, polypropylene glycol and block copolymer of ethylene glycol and propylene glycol were crosslinked by triisocyanate to form water swellable, rubbery polymer. The equilibrium swelling of the hydrogels ranged from 3% to 60% according to the hydrophobic-hydrophilic properties of the prepolymers. Model drugs, sodium salicylate and prednisolone were incorporated in the polymer matrices by swelling loading. Physical properties of the drugs affected the drug release mechanisms due to the change in the swelling behaviors of the polymeric devices. Zero order release was observed in the case of relatively hydrophobic polymer matrices.