Permeation Characteristics of Poly(Hydroxypropyl Methacrylate) membrane having Tertiary Amine Moiety

Tertiary Amine을 포함하는 Hydroxypropyl Methacrylate 고분자막의 투과특성

  • Hon, Jae-Min (Department of Chemical Technology, Seoul National University) ;
  • Shim, Jyong-Sup (Department of Chemical Technology, Seoul National University)
  • 홍재민 (서울대학교 공과대학 공업화학과) ;
  • 심정섭 (서울대학교 공과대학 공업화학과)
  • Received : 1990.11.27
  • Published : 1990.12.31

Abstract

Hydroxypropyl methacrylate polymeric membranes having tertiary amine moiety were prepared to control the release rate of insulin in response to the concentration of glucose. Hydroxypropyl methacrylate was copolymerized with N, N'-diethylaminoethylacrylate. Its water content was increased with decreasing the pH of the medium and was reversible with variation of the pH of the medium. The permeation coefficient of insulin through copolymer membrane was also increased with decreasing the pH of the medium. Combining this copolymer membrane and the glucose oxidase immobilized membrane as a sensor for glucose, composite membrane was prepared. The permeability of this composite membrane was increased with addition of glucose.

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