Anticomplementary and Antitumor Activities of the Alkali Extract from the Mycelia of Lentinus edodes 1'11105

Lentinus edodes IY105 알칼리 추출물의 보체계활성 및 항종양효과

  • Lee, June-Woo (Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Chung, Chun-Hee (Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Lee, Kweon-Haeng (Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.) ;
  • Jeong, Hoon (Central Institute of Research, Il Yang Pharmaceutical Co. Ltd.)
  • 이준우 (일양약품(주) 중앙연구소) ;
  • 정천희 (일양약품(주) 중앙연구소) ;
  • 이권행 (일양약품(주) 중앙연구소) ;
  • 정훈 (일양약품(주) 중앙연구소)
  • Published : 1990.12.01

Abstract

Alkali extract obtained from mycelia of Lentinus edodes IY105 was shown to have potent anticomplementary activity and alternative complementary activity in vitro. It was also shown to activate reticuloendothelial system of ICR mice in the carbon clearance. Amount of carbohydrates and protein of the extract were 17% and 42% respectively. It was found that carbohydrates were consisted of 5 monosaccharides and protein was consisted of 16 amino acids. Antitumor activity was observed in the alkali extract treated group of sarcoma 180 bearing ICR mice.

Keywords

Lentinus edodes;anticomplementary activity;total complement hemolytic activity;alternative complement hemolytic activity;total complment system;reticuloendothelial system;antitumor activity