생쥐 대식세포의 종양세포 치사활성에 미치는 인삼분획물과 지방다당류의 영향

  • Choe, Sang-Un (Korea Research Institute of Chemical Technology) ;
  • Jeong, No-Pal (Department of Biology, College of Science, Yonsei University) ;
  • Kim, Se-Chang (Department of Biology, Paichai University)
  • 최상운 (한국화학연구소 의약활성연구실) ;
  • 정노팔 (연세대학교 이과대학 생물학과, 배재대학교 생물학과) ;
  • 김세창 (배재대학교 생물학과)
  • Published : 1990.12.01

Abstract

This experiment was performed to investigate the effects of ginseng saponin fractions (total saponin, triol saponin. diol saponin) and lipopolysacrharide (LPS) on the tllmoricidal activity of macrophage. The ginseng saponin fractions had little effect on the tumoricidal activity of macrophage (less than 10%). When the ginseng saponin fractions were treated with LPS, the effects of tumoricidal activation of macrophage increased a relatively high percent, and the total saponin and triol saponin (20-35%) were ulore effectual than diol saponin (15-25%). The effects of ginseng saponin and LPS on the tumoricidal activity of macrophage were mediated by the induction of macrophage-release factor(5) which has(have) the capacity of tumor cell killing. And the quantity of the (actors) was(were) increased by the contact of macrophage with tumor cell.