Inhibitory Effect on Adjuvant Arthritis and Other Pharmacological Profile of Gamma-Interferon, LBD-001

감마 인터페론, LBD-001의 Adjuvant 관절염 억제작용 및 기타 일반 약리작용

  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Kim, Jae-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Kim, Oon-Ja (Natural Products Research Institute, Seoul National University) ;
  • Kim, Jung-Keun (Natural Products Research Institute, Seoul National University)
  • 이은방 (서울대학교 생약연구소) ;
  • 김제현 (서울대학교 생약연구소) ;
  • 김운자 (서울대학교 생약연구소) ;
  • 김정근 (서울대학교 생약연구소)
  • Published : 1990.06.28

Abstract

The recombinant gamma-interferon (LBD-001) which was produced by yeast as host system was investigated on the pharmacological activities. This gamma-interferon exhibited potent inhibitory effect on adjuvant induced arthritis, but no effect on carrageenin induced paw edema in rats. It did not show any sedative, anticonvulsive, analgesic and hypothermic activities in animals. It also had no influences on isolated tracheal muscle and ileum of guinea pig, isolated uterus and fundus strip of rats, and on blood pressure and respiration in situ experiments of rabbits.