Effect of chelating agent and organic acid on strontium distribution in Wistar rats

착화제와 유기산이 Wistar rat체내의 Sr 분포에 미치는 영향

  • Lee, Kee-Ho (Laboratory of Biochemistry, Korea Cancer Center Hospital, KAERI) ;
  • Lee, Je-Ho (Laboratory of Biochemistry, Korea Cancer Center Hospital, KAERI) ;
  • Park, Sang-Yoon (Laboratory of Biochemistry, Korea Cancer Center Hospital, KAERI) ;
  • Lee, Seung-Hoon (Laboratory of Biochemistry, Korea Cancer Center Hospital, KAERI) ;
  • Ryu, Yong-Wun (Laboratory of Radiation Medicine, Korea Cancer Center Hospital, KAERI) ;
  • Yun, Taik-Koo (Laboratory of Cancer Pathology Korea Cancer Center Hospital, KAERI)
  • 이기호 (한국원자력연구소, 원자력병원 생화학 연구실) ;
  • 이제호 (한국원자력연구소, 원자력병원 생화학 연구실) ;
  • 박상윤 (한국원자력연구소, 원자력병원 생화학 연구실) ;
  • 이승훈 (한국원자력연구소, 원자력병원 생화학 연구실) ;
  • 유용운 (한국원자력연구소, 원자력병원 방사선 의학연구실) ;
  • 윤택구 (한국원자력연구소, 원자력병원 암병리 연구실)
  • Published : 1990.12.25

Abstract

$^{88}SrCl_2$ was injected to the tail vein of Wistar rats and investigated its distribution and clearance in the tissues and blood. We also measured the changes in Sr binding to the blood plasma protein by administrating chelating agents and organic acids. For the blood, 60% of the Sr occurred in the plasma and 40% on the cell membrane. Fifty percent of Sr in the blood plasma was bound to plasma protein. Sr on the cell membrane seemed to be bound loosely. The binding in the lymphocyte was higher than in the erythrocyte .and granulocyte. Within one hour Sr was quickly disappeared from the blood stream, to be accumulated in the bone. Twenty four hours after the injection, Sr decreased rapidly in the organs of soft tissue, but slowly in the bone. The binding of Sr to plasma protien decreased from 57% of the control to 27-33% in the group treated with chelating agents, EDTA, EGTA and DTPA and to 19% and 40% in the groups treated with organic acids, citrate and oxalate, respectively.

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