pH-Dependent Drug Release from Polymethacrylic Acid Hydrogel Matrix

Polymethacrylic Acid 하이드로겔 매트릭스로부터의 pH 의존성 약물 방출

  • 김경충 (이화여자대학교 약학대학) ;
  • 김길수 (이화여자대학교 약학대학) ;
  • 이승진 (이화여자대학교 약학대학)
  • Published : 1989.12.20


Drug release experiments were performed based on pH-sensitive swelling behaviors of polymethacrylic acid. 5-Fluorouracil as a nonionic model drug revealed release patterns depending solely on pH-dependent swelling kinetics of polymethacrylic acid. In contrast, release of propranolol hydrochloride as a cationic model drug was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics. Accordingly, a zero-order release pattern was obtained at pH 7, which was distinguished from the general matrix type drug release pattern.