- Volume 12 Issue 2
When ginseng saponin fractions were treated with secretion regulatory agents, it increased cAMP level at the case of thyrotropin (but the amounts were small). Total saponin increased cAMP level at DEcAMP and isoproterenol, and decreased the level at carbachol and propranolol, but at NaF it had little effect. When diol saponin or triol saponin were treated with secretion regulatory agents, biol saponin decreased cAMP level but triol saponin increased it except for isoproterenol. Also, in propra%olol, which inhibits the increase of CAMP level, diol and triol saponin showed crossing effect, too. From the above results, ginseng saponin fractions are believed that it has the, effects of promotion or inhibition on cAMP production in the thyroid , both diol saponin and triol saponin have crossing effect on thyroid hormone secretion regulatory agents. The normalizatin action of ginseng saponin fractions is notable at the case of NaF and carbachol.